Vta1 vesicle (multivesicular body) trafficking 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vta1provided by MGI
Official Full Name: vesicle (multivesicular body) trafficking 1provided by MGI
Primary source: MGI:MGI:1913451
See related: Ensembl:ENSMUSG00000019868 AllianceGenome:MGI:1913451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LIP5; SBP1; 1110001D18Rik; 1110059P08Rik
Summary: Predicted to enable protein C-terminus binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and viral budding. Predicted to act upstream of or within protein transport. Located in cytoplasm. Is expressed in cortical plate. Orthologous to human VTA1 (vesicle trafficking 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 23.2), whole brain E14.5 (RPKM 22.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A2; 10 5.5 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (14531077..14581233, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (14654760..14705542, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIP5 protein expression in a mouse tissue panel and various rodent and human tissues were studied.[LIP5]
Title: The lysosomal trafficking regulator interacting protein-5 localizes mainly in epithelial cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133293 (e-PCR)
- UniSTS:216576

RH127170 (e-PCR)
- UniSTS:208496

AU040813 (e-PCR)
- UniSTS:159954

Readthrough Gm57851

Readthrough gene: Gm57851, Included gene: Gje1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vacuolar protein sorting-associated protein VTA1 homolog

Names: SKD1-binding protein 1; Vps20-associated 1 homolog; lysosomal trafficking regulator interacting protein-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.