Dynlt2b dynein light chain Tctex-type 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dynlt2bprovided by MGI
Official Full Name: dynein light chain Tctex-type 2Bprovided by MGI
Primary source: MGI:MGI:1913311
See related: Ensembl:ENSMUSG00000014075 AllianceGenome:MGI:1913311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tctex1d2; 0610012D17Rik; 2410011K15Rik
Summary: Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in cilium organization; regulation of cilium assembly; and regulation of intraciliary retrograde transport. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Predicted to colocalize with ciliary base and cytoskeleton. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 54.6), bladder adult (RPKM 7.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 22.69 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (32238520..32247917)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (32419702..32429099)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tctex1d2 is a novel syntaxin 4 binding protein that functions as a negative regulator of GLUT4 plasma membrane translocation through inhibition of the Doc2b-syntaxin 4 interaction
Title: Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake.
0610012D17Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in intraciliary retrograde transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of intraciliary retrograde transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with axoneme	ISO Inferred from Sequence Orthology more info
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
colocalizes_with ciliary base	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
colocalizes_with interphase microtubule organizing center	ISO Inferred from Sequence Orthology more info
colocalizes_with spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein light chain Tctex-type protein 2B

Names: Tctex1 domain containing 2; tctex1 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.