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    Rogdi rogdi homolog [ Mus musculus (house mouse) ]

    Gene ID: 66049, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rogdiprovided by MGI
    Official Full Name
    rogdi homologprovided by MGI
    Primary source
    MGI:MGI:1913299
    See related
    Ensembl:ENSMUSG00000022540 AllianceGenome:MGI:1913299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lzf; 0610011C19Rik
    Summary
    Acts upstream of or within hemopoiesis and positive regulation of cell population proliferation. Predicted to be located in nuclear envelope. Predicted to be part of RAVE complex. Is expressed in central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Kohlschutter-Tonz syndrome. Orthologous to human ROGDI (rogdi atypical leucine zipper). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 83.8), kidney adult (RPKM 80.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A1; 16 2.49 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4826593..4831438, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5008729..5013574, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene septin 12 Neighboring gene STARR-positive B cell enhancer ABC_E7426 Neighboring gene small integral membrane protein 22 Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) Neighboring gene STARR-positive B cell enhancer ABC_E1180 Neighboring gene ubinuclein 1 Neighboring gene predicted gene, 23483

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic approach and phenotype-based complementation screening for identification of stroma cell-derived proteins involved in cell proliferation. Tulin EE, et al. Exp Cell Res, 2002 Jan 1. PMID 11740862
    2. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article
    3. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
    4. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
    5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Rogdi knockout mouse is a model for Kohlschutter-Tonz syndrome.
      Title: The Rogdi knockout mouse is a model for Kohlschütter-Tönz syndrome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amelogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circadian behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within enamel mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RAVE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein rogdi homolog
    Names
    leucine zipper domain protein
    leucine-zipper-containing LZF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133185.2 → NP_573448.2  protein rogdi homolog

      See identical proteins and their annotated locations for NP_573448.2

      Status: VALIDATED

      Source sequence(s)
      AK002523, BU604779, CD363552
      Consensus CDS
      CCDS79419.1
      UniProtKB/Swiss-Prot
      Q3TDK6, Q8BL37, Q922N4, Q923H8
      Related
      ENSMUSP00000144481.2, ENSMUST00000202281.4
      Conserved Domains (1) summary
      pfam10259
      Location:18 → 276
      Rogdi_lz; Rogdi leucine zipper containing protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4826593..4831438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160082.1 → XP_036015975.1  protein rogdi homolog isoform X1

      Conserved Domains (1) summary
      pfam10259
      Location:18 → 169
      Rogdi_lz; Rogdi leucine zipper containing protein

    RNA

    1. XR_004939203.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TDK6.2 GenPept UniProtKB/Swiss-Prot:Q3TDK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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