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    Lrp10 low-density lipoprotein receptor-related protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 65107, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lrp10provided by MGI
    Official Full Name
    low-density lipoprotein receptor-related protein 10provided by MGI
    Primary source
    MGI:MGI:1929480
    See related
    Ensembl:ENSMUSG00000022175 AllianceGenome:MGI:1929480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrp9
    Summary
    Enables low-density lipoprotein particle receptor activity. Acts upstream of or within inner ear development; lipid metabolic process; and lipid transport. Is integral component of membrane. Is expressed in several structures, including adrenal gland; brain; genitourinary system; liver; and meninges. Orthologous to human LRP10 (LDL receptor related protein 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 199.5), adrenal adult (RPKM 148.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C2; 14 27.8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54701260..54707749)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54464137..54470292)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 14 (membrane-inserted) Neighboring gene STARR-positive B cell enhancer mm9_chr14:55067911-55068211 Neighboring gene STARR-seq mESC enhancer starr_36736 Neighboring gene predicted gene, 24424 Neighboring gene STARR-positive B cell enhancer ABC_E8559 Neighboring gene STARR-positive B cell enhancer ABC_E5436 Neighboring gene rad and gem related GTP binding protein 2 Neighboring gene predicted gene, 41153

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Intracellular trafficking of LRP9 is dependent on two acidic cluster/dileucine motifs. Boucher R, et al. Histochem Cell Biol, 2008 Aug. PMID 18461348
    2. Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family. Jeong YH, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 20005200
    3. Calnuc binds to LRP9 and affects its endosomal sorting. Brodeur J, et al. Traffic, 2009 Aug. PMID 19497050
    4. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. Sugiyama T, et al. Biochemistry, 2000 Dec 26. PMID 11123907
    5. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Pons S, et al. Mol Cell Biol, 1995 Aug. PMID 7542745, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (5) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables low-density lipoprotein particle receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-density lipoprotein particle receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within inner ear development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 10
    Names
    LRP-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022993.3 → NP_075369.2  low-density lipoprotein receptor-related protein 10 precursor

      See identical proteins and their annotated locations for NP_075369.2

      Status: VALIDATED

      Source sequence(s)
      BC052378, CAAA01001439
      Consensus CDS
      CCDS27089.1
      UniProtKB/Swiss-Prot
      Q3UNT0, Q7TQH7, Q7TS95, Q921T0, Q9EPE8
      UniProtKB/TrEMBL
      Q3TD85, Q3V1Z1
      Related
      ENSMUSP00000022782.9, ENSMUST00000022782.10
      Conserved Domains (2) summary
      cd00041
      Location:193 → 303
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:141 → 175
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54701260..54707749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519358.3 → XP_006519421.1  low-density lipoprotein receptor-related protein 10 isoform X1

      UniProtKB/TrEMBL
      Q3TD85, Q3V1Z1
      Conserved Domains (3) summary
      cd00041
      Location:68 → 178
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:16 → 50
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam12999
      Location:219 → 269
      PRKCSH-like; Glucosidase II beta subunit-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQH7.2 GenPept UniProtKB/Swiss-Prot:Q7TQH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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