Lpar3 lysophosphatidic acid receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpar3provided by MGI
Official Full Name: lysophosphatidic acid receptor 3provided by MGI
Primary source: MGI:MGI:1929469
See related: Ensembl:ENSMUSG00000036832 AllianceGenome:MGI:1929469
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Edg7; lpA3
Summary: Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and phospholipid binding activity. Involved in gene expression. Acts upstream of or within several processes, including bleb assembly; positive regulation of MAPK cascade; and positive regulation of collateral sprouting. Located in axon. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 14.3), testis adult (RPKM 9.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 71.03 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (145926716..145991969)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (146220961..146286214)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells.
Title: Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells.
LPA3-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice.
Title: LPA(3)-mediated lysophosphatidic acid signaling promotes postnatal heart regeneration in mice.
Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
Title: Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
Mechanical and signaling mechanisms that guide pre-implantation embryo movement.
Title: Mechanical and signaling mechanisms that guide pre-implantation embryo movement.
inhibition of LPA1/3 receptor abolished lysophosphatidic acid-induced elevation of the osteogenic and angiogenic capability of pre-osteoblasts.
Title: Lysophosphatidic acid enhanced the osteogenic and angiogenic capability of osteoblasts via LPA1/3 receptor.
Osteoglycin negatively regulates cardiac fibrotic remodelling by attenuating myofibroblast proliferation and migration through LPA3-mediated and Rho/ROCK-dependent inhibition of MT1-MMP translocation, MMP2 activation and EGFR transactivation.
Title: Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling.
we demonstrate that LPA1/3 antagonism mildly reduced plasma LDL cholesterol levels. Therefore, pharmacological inhibition of LPA1/3 receptors may prove a promising approach to diminish atherosclerosis development.
Title: Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice.
These results indicate that ATX-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways.
Title: Autotaxin-lysophosphatidic acid-LPA(3) signaling at the embryo-epithelial boundary controls decidualization pathways.
Lpar3(-/-) female mice had delayed embryo implantation.
Title: Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation.
These results suggest that LPA3 receptor-mediated amplification of spinal LPA production is required for the development of paclitaxel-induced neuropathic pain.
Title: Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488724

Edg7 (e-PCR), detects polymorphism
- UniSTS:259393

Edg7 (e-PCR), detects polymorphism
- UniSTS:259394

NoName (e-PCR)
- UniSTS:493949

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid receptor activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bleb assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 3

Names: LPA receptor 3; LPA-3; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7; lysophosphatidic acid receptor Edg-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022983.4 → NP_075359.1 lysophosphatidic acid receptor 3

See identical proteins and their annotated locations for NP_075359.1

Status: VALIDATED

Source sequence(s)

AC122513, AK042084

Consensus CDS

CCDS17901.1

UniProtKB/Swiss-Prot

Q9EQ31

UniProtKB/TrEMBL

Q544B4

Related

ENSMUSP00000037712.3, ENSMUST00000039164.4

Conserved Domains (2) summary

pfam00001
Location:48 → 293

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:42 → 309

7tm_4; Olfactory receptor