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    Lpin3 lipin 3 [ Mus musculus (house mouse) ]

    Gene ID: 64899, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lpin3provided by MGI
    Official Full Name
    lipin 3provided by MGI
    Primary source
    MGI:MGI:1891342
    See related
    Ensembl:ENSMUSG00000027412 AllianceGenome:MGI:1891342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4023; 9130206L11Rik
    Summary
    Enables phosphatidate phosphatase activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; fatty acid catabolic process; and triglyceride biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; skin; and trachea. Orthologous to human LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 11.4), large intestine adult (RPKM 11.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H2; 2 80.98 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (160722590..160747920)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (160880670..160906000)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene STARR-positive B cell enhancer ABC_E6012 Neighboring gene predicted gene, 35129 Neighboring gene uncharacterized LOC118568533 Neighboring gene elastin microfibril interfacer 3 Neighboring gene predicted gene, 35181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3. Boroda S, et al. J Biol Chem, 2017 Dec 15. PMID 28982975, Free PMC Article
    2. Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. Zhang P, et al. J Clin Invest, 2019 Jan 2. PMID 30507612, Free PMC Article
    3. Lipin-1 and lipin-3 together determine adiposity in vivo. Csaki LS, et al. Mol Metab, 2014 Apr. PMID 24634820, Free PMC Article
    4. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. Donkor J, et al. J Biol Chem, 2007 Feb 9. PMID 17158099
    5. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Péterfy M, et al. Nat Genet, 2001 Jan. PMID 11138012

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis.
      Title: Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
    2. Data suggest that phosphorylation does not affect catalytic activity of lipin 3 or its ability to associate with phosphatidic acid in vitro; different polybasic domains in lipin 1 and lipin 3 are responsible for phospho-regulation on the former but not the latter enzyme.
      Title: The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.
    3. Lipin-3 exhibits phosphatidate phosphatase type-1 (PAP1) activity, which has a key role in glycerolipid synthesis.
      Title: Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4023, MGC143991, MGC143992

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidate phosphatase LPIN3
    NP_001186047.1
    NP_075021.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199118.1 → NP_001186047.1  phosphatidate phosphatase LPIN3

      See identical proteins and their annotated locations for NP_001186047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK163833, BB659464
      Consensus CDS
      CCDS16998.1
      UniProtKB/Swiss-Prot
      Q3TQ75, Q8C7R9, Q99PI4
      UniProtKB/TrEMBL
      A2A4B1, Q149B0
      Related
      ENSMUSP00000043053.7, ENSMUST00000040872.13
      Conserved Domains (4) summary
      COG5083
      Location:1 → 816
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:589 → 814
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:435 → 525
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. NM_022883.3 → NP_075021.1  phosphatidate phosphatase LPIN3

      See identical proteins and their annotated locations for NP_075021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK220228, BB016248
      Consensus CDS
      CCDS16998.1
      UniProtKB/Swiss-Prot
      Q3TQ75, Q8C7R9, Q99PI4
      UniProtKB/TrEMBL
      A2A4B1, Q149B0
      Related
      ENSMUSP00000105082.3, ENSMUST00000109456.9
      Conserved Domains (4) summary
      COG5083
      Location:1 → 816
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:589 → 814
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:435 → 525
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      160722590..160747920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_374500.4 RNA Sequence

    2. XR_374499.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PI4.1 GenPept UniProtKB/Swiss-Prot:Q99PI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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