Scube1 signal peptide, CUB domain, EGF-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scube1provided by MGI
Official Full Name: signal peptide, CUB domain, EGF-like 1provided by MGI
Primary source: MGI:MGI:1890616
See related: Ensembl:ENSMUSG00000016763 AllianceGenome:MGI:1890616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 7330410C13Rik; A630023E24Rik
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, including allantois; embryo ectoderm; embryo mesenchyme; forelimb bud; and genitourinary system. Orthologous to human SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 12.6), CNS E11.5 (RPKM 8.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 39.4 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (83486784..83609252, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (83602583..83725051, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia.
Title: Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia.
Epidermal growth factor-like repeats of SCUBE1 derived from platelets are critical for thrombus formation.
Title: Epidermal growth factor-like repeats of SCUBE1 derived from platelets are critical for thrombus formation.
SCUBE1 directly binds to BMP7 and its receptors, functioning as a BMP co-receptor to promote BMP7 signaling.
Title: SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury.
SCUBE1 participates in platelet aggregation by bridging adjacent activated platelets in thrombosis. Blockade of soluble SCUBE1 might represent a novel antithrombotic strategy.
Title: Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis.
SCUBE1 may be involved in the regulation of tubular cell proliferation and re-epithelialization during the resolution of kidney injury.
Title: SCUBE1, a novel developmental gene involved in renal regeneration and repair.
During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth, suggestina a role for Scube1 during early craniofacial development.
Title: Scube1 is expressed during facial development in the mouse.
These results support the dual roles of SCUBE1 on brain morphogenesis and cell-cell adhesions through its distinct domain function.
Title: Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI604862 (e-PCR)
- UniSTS:165952

Scube1 (e-PCR), detects polymorphism
- UniSTS:186753

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal peptide, CUB and EGF-like domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271472.1 → NP_001258401.1 signal peptide, CUB and EGF-like domain-containing protein 1 isoform a precursor

See identical proteins and their annotated locations for NP_001258401.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AK041590, AL583887, BC066066, CJ104466

Consensus CDS

CCDS70655.1

UniProtKB/Swiss-Prot

Q6NZL8, Q8C9Q4, Q9EQC6

UniProtKB/TrEMBL

A2A442

Related

ENSMUSP00000016907.8, ENSMUST00000016907.8

Conserved Domains (5) summary

cd00041
Location:828 → 939

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam07699
Location:776 → 823

GCC2_GCC3; GCC2 and GCC3

pfam12947
Location:37 → 72

EGF_3; EGF domain

pfam14670
Location:275 → 310

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:348 → 384

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001271473.1 → NP_001258402.1 signal peptide, CUB and EGF-like domain-containing protein 1 isoform c precursor

See identical proteins and their annotated locations for NP_001258402.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AL583887, BC080278, CJ104466

Consensus CDS

CCDS70654.1

UniProtKB/TrEMBL

A2A442, Q68EF9

Related

ENSMUSP00000044835.6, ENSMUST00000043634.12

Conserved Domains (5) summary

cd00041
Location:717 → 828

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam07699
Location:665 → 712

GCC2_GCC3; GCC2 and GCC3

pfam12947
Location:37 → 72

EGF_3; EGF domain

pfam14670
Location:164 → 199

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:237 → 273

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_022723.3 → NP_073560.2 signal peptide, CUB and EGF-like domain-containing protein 1 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AK041590, AL583887, BC080278, CJ104466

Consensus CDS

CCDS49684.1

UniProtKB/TrEMBL

A2A442

Related

ENSMUSP00000130131.2, ENSMUST00000171496.9

Conserved Domains (5) summary

cd00041
Location:798 → 909

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam07699
Location:746 → 793

GCC2_GCC3; GCC2 and GCC3

pfam12947
Location:37 → 72

EGF_3; EGF domain

pfam14670
Location:245 → 280

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:318 → 354

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

83486784..83609252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521242.5 → XP_006521305.1 signal peptide, CUB and EGF-like domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

A2A442

Conserved Domains (5) summary

cd00041
Location:867 → 978

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam07699
Location:815 → 862

Ephrin_rec_like; Putative ephrin-receptor like

pfam12947
Location:76 → 111

EGF_3; EGF domain

pfam14670
Location:314 → 349

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:387 → 423

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_017316719.2 → XP_017172208.1 signal peptide, CUB and EGF-like domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A2A442

Conserved Domains (5) summary

cd00041
Location:867 → 978

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam07699
Location:815 → 862

Ephrin_rec_like; Putative ephrin-receptor like

pfam12947
Location:76 → 111

EGF_3; EGF domain

pfam14670
Location:314 → 349

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:387 → 423

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_036159534.1 → XP_036015427.1 signal peptide, CUB and EGF-like domain-containing protein 1 isoform X3

Conserved Domains (3) summary

pfam12947
Location:76 → 111

EGF_3; EGF domain

pfam14670
Location:314 → 349

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:387 → 423

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...