Dpys dihydropyrimidinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpysprovided by MGI
Official Full Name: dihydropyrimidinaseprovided by MGI
Primary source: MGI:MGI:1928679
See related: Ensembl:ENSMUSG00000022304 AllianceGenome:MGI:1928679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DHP; DHPase; 1200017I10Rik; 1300004I01Rik
Summary: Enables dihydropyrimidinase activity and phosphoprotein binding activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Located in cytosol. Is expressed in cranium. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 55.6), liver E18 (RPKM 26.8) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 15.53 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (39631881..39720866, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (39768485..39857470, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dpys (e-PCR), detects polymorphism
- UniSTS:546743

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables amino acid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydropyrimidinase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydropyrimidinase activity	ISO Inferred from Sequence Orthology more info
enables dihydropyrimidinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dihydropyrimidinase activity	TAS Traceable Author Statement more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thymine binding	ISO Inferred from Sequence Orthology more info
enables thymine binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables uracil binding	ISO Inferred from Sequence Orthology more info
enables uracil binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in CMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in beta-alanine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in beta-alanine metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in dCMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dUMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleobase catabolic process	ISO Inferred from Sequence Orthology more info
involved_in thymine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in thymine catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in uracil catabolic process	ISO Inferred from Sequence Orthology more info
involved_in uracil catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in uracil metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dihydropyrimidinase

Names: dihydropyrimidine amidohydrolase; hydantoinase

NP_001157938.1

EC 3.5.2.2

NP_073559.3

EC 3.5.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164466.1 → NP_001157938.1 dihydropyrimidinase

See identical proteins and their annotated locations for NP_001157938.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC158776, AK004822

Consensus CDS

CCDS27445.1

UniProtKB/Swiss-Prot

Q99PP1, Q9DBK3, Q9DBP7, Q9EQF5

Related

ENSMUSP00000105935.2, ENSMUST00000110306.9

Conserved Domains (2) summary

PRK09060
Location:7 → 447

PRK09060; dihydroorotase; Validated

cd01314
Location:7 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
NM_022722.3 → NP_073559.3 dihydropyrimidinase

See identical proteins and their annotated locations for NP_073559.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC158776, AK004822, AK004899

Consensus CDS

CCDS27445.1

UniProtKB/Swiss-Prot

Q99PP1, Q9DBK3, Q9DBP7, Q9EQF5

Related

ENSMUSP00000022915.4, ENSMUST00000022915.11

Conserved Domains (2) summary

PRK09060
Location:7 → 447

PRK09060; dihydroorotase; Validated

cd01314
Location:7 → 460

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...