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    Nmi N-myc (and STAT) interactor [ Mus musculus (house mouse) ]

    Gene ID: 64685, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Nmiprovided by MGI
    Official Full Name
    N-myc (and STAT) interactorprovided by MGI
    Primary source
    MGI:MGI:1928368
    See related
    Ensembl:ENSMUSG00000026946 AllianceGenome:MGI:1928368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Involved in positive regulation of defense response; response to virus; and toll-like receptor 4 signaling pathway. Acts upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Located in extracellular space. Is expressed in genitourinary system; limb; and retina. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.8), large intestine adult (RPKM 5.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C1.1; 2 29.98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (51838517..51863241, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (51948498..51973489, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13495 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene STARR-seq mESC enhancer starr_04475 Neighboring gene tumor necrosis factor alpha induced protein 6 Neighboring gene STARR-seq mESC enhancer starr_04477 Neighboring gene replication timing regulatory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors. Pruitt HC, et al. Oncogene, 2018 Mar. PMID 29326438, Free PMC Article
    2. IFP35 family proteins promote neuroinflammation and multiple sclerosis. Jing X, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34362845, Free PMC Article
    3. Nmi interacts with Hsp105β and enhances the Hsp105β-mediated Hsp70 expression. Saito Y, et al. Exp Cell Res, 2014 Sep 10. PMID 25088258
    4. NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21. Ouyang W, et al. Am J Respir Cell Mol Biol, 2021 Jul. PMID 33761305
    5. Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7. Wang J, et al. J Immunol, 2013 Sep 15. PMID 23956435

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
      Title: NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
    2. IFP35 family proteins promote neuroinflammation and multiple sclerosis.
      Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
    3. NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21.
      Title: NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21.
    4. Nmi has a distinct role in the differentiation process of mammary luminal epithelial cell compartment and developmental aberrations resulting from Nmi absence contribute to metastasis.
      Title: Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.
    5. Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways.
      Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
    6. These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7
      Title: Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of type I interferon production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-myc-interactor
    Names
    N-mcy (and STAT) interactor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141948.2 → NP_001135420.1  N-myc-interactor isoform a

      See identical proteins and their annotated locations for NP_001135420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      Consensus CDS
      CCDS16031.1
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82, Q4FJP2
      Related
      ENSMUSP00000108325.3, ENSMUST00000112705.9
      Conserved Domains (2) summary
      pfam07334
      Location:30 → 105
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:204 → 292
      NID; Nmi/IFP 35 domain (NID)

    2. NM_001141949.2 → NP_001135421.1  N-myc-interactor isoform a

      See identical proteins and their annotated locations for NP_001135421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      Consensus CDS
      CCDS16031.1
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82, Q4FJP2
      Related
      ENSMUSP00000120647.2, ENSMUST00000145481.8
      Conserved Domains (2) summary
      pfam07334
      Location:30 → 105
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:204 → 292
      NID; Nmi/IFP 35 domain (NID)

    3. NM_001421887.1 → NP_001408816.1  N-myc-interactor isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82

    4. NM_001421888.1 → NP_001408817.1  N-myc-interactor isoform b

      Status: VALIDATED

      Source sequence(s)
      AL929026

    5. NM_001421889.1 → NP_001408818.1  N-myc-interactor isoform c

      Status: VALIDATED

      Source sequence(s)
      AL929026

    6. NM_001421890.1 → NP_001408819.1  N-myc-interactor isoform c

      Status: VALIDATED

      Source sequence(s)
      AL929026

    7. NM_001421891.1 → NP_001408820.1  N-myc-interactor isoform c

      Status: VALIDATED

      Source sequence(s)
      AL929026

    8. NM_019401.3 → NP_062274.1  N-myc-interactor isoform a

      See identical proteins and their annotated locations for NP_062274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL929026
      Consensus CDS
      CCDS16031.1
      UniProtKB/Swiss-Prot
      O35309, Q99M49
      UniProtKB/TrEMBL
      Q3UJ82, Q4FJP2
      Related
      ENSMUSP00000028314.3, ENSMUST00000028314.9
      Conserved Domains (2) summary
      pfam07334
      Location:30 → 105
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:204 → 292
      NID; Nmi/IFP 35 domain (NID)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      51838517..51863241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35309.1 GenPept UniProtKB/Swiss-Prot:O35309

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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