Ngb neuroglobin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ngbprovided by MGI
Official Full Name: neuroglobinprovided by MGI
Primary source: MGI:MGI:2151886
See related: Ensembl:ENSMUSG00000021032 AllianceGenome:MGI:2151886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables oxygen carrier activity. Acts upstream of or within oxygen transport. Predicted to be located in mitochondrion; neuron projection; and perikaryon. Is expressed in brain; future brain; retina; and testis. Orthologous to human NGB (neuroglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 22.2), stomach adult (RPKM 7.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D2; 12 41.29 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (87144305..87149313, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (87097531..87102539, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice.
Title: Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice.
Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics.
Title: Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics.
Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy.
Title: Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy.
A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
Title: A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
These results indicate Ngb to be involved in and affected by the SOD1(G93A) pathology, which could in part be attributed to its role in halting destabilizing events of mitochondrial swelling and phenotypes.
Title: Non-Methylation-Linked Mechanism of REST-Induced Neuroglobin Expression Impacts Mitochondrial Phenotypes in a Mouse Model of Amyotrophic Lateral Sclerosis.
Ngb promotes axon regeneration via oxygen-Ngb-p38-GAP43 signaling during ischemia/reperfusion.
Title: Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal.
This is the first report demonstrating a similar pattern of Ngb expression during disease progression in the brains of R6/2 mice.
Title: Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease.
NGB proved to act cytoprotectively during MI in the acute setting while this effect was less pronounced in the atherosclerosis model.
Title: Cytoprotective effects of transgenic neuroglobin overexpression in an acute and chronic mouse model of ischemic heart disease.
Study showed that in Neuroglobin (Ngb) knockout mice, distortion-product otoacoustic emissions thresholds were moderately augmented in the range of 5-18kHz. Results suggest that the lack of NgB, results in only marginal deficits in hearing ability.
Title: Hearing Without Neuroglobin.
Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning
Title: Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	ISO Inferred from Sequence Orthology more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in oxygen transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oxygen transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuroglobin

Names: nitrite reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001294308.1 → NP_001281237.1 neuroglobin isoform 1

See identical proteins and their annotated locations for NP_001281237.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC132609, AW489131

Consensus CDS

CCDS79141.1

UniProtKB/TrEMBL

Q3USR6

Related

ENSMUSP00000105806.3, ENSMUST00000110177.9

Conserved Domains (1) summary

cd08920
Location:1 → 152

Ngb; Neuroglobins
NM_022414.2 → NP_071859.1 neuroglobin isoform 2

See identical proteins and their annotated locations for NP_071859.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

BC024263

Consensus CDS

CCDS36501.1

UniProtKB/Swiss-Prot

Q9ER97

UniProtKB/TrEMBL

Q5ZPR7

Related

ENSMUSP00000021420.8, ENSMUST00000021420.14

Conserved Domains (1) summary

cd08920
Location:1 → 148

Ngb; Neuroglobins