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    Moap1 modulator of apoptosis 1 [ Mus musculus (house mouse) ]

    Gene ID: 64113, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Moap1provided by MGI
    Official Full Name
    modulator of apoptosis 1provided by MGI
    Primary source
    MGI:MGI:1915555
    See related
    Ensembl:ENSMUSG00000096458 AllianceGenome:MGI:1915555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map-1; Pnma4; MmMOAP1
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in apoptotic signaling pathway; positive regulation of apoptotic process; and positive regulation of release of cytochrome c from mitochondria. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol; mitochondrial outer membrane; and nucleus. Is expressed in nervous system and sensory organ. Orthologous to human MOAP1 (modulator of apoptosis 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 10.8), testis adult (RPKM 9.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 52.14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102706089..102709920, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102739830..102743661, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase Neighboring gene VISTA enhancer mm491 Neighboring gene microRNA 1936 Neighboring gene STARR-seq mESC enhancer starr_33110 Neighboring gene predicted gene, 30296 Neighboring gene STARR-seq mESC enhancer starr_33116 Neighboring gene STARR-positive B cell enhancer ABC_E9862 Neighboring gene STARR-positive B cell enhancer ABC_E9390 Neighboring gene predicted gene 20604 Neighboring gene STARR-seq mESC enhancer starr_33118 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene GON7 subunit of KEOPS complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice. Zhao H, et al. Mol Neurobiol, 2019 Mar. PMID 30003515, Free PMC Article
    2. MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. Tan CT, et al. Cell Rep, 2016 Jun 28. PMID 27320914
    3. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. Tan CT, et al. EMBO Rep, 2021 Jan 7. PMID 33393215, Free PMC Article
    4. RASSF6 is a novel member of the RASSF family of tumor suppressors. Allen NP, et al. Oncogene, 2007 Sep 13. PMID 17404571
    5. The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore. Chang HC, et al. Autophagy, 2021 Nov. PMID 33783314, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
      Title: MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
    2. These data suggest that MOAP-1 is required in the regulation of stress response in the dorsal raphe nucleus. Crosstalk between BDNF and 5-HT appears to play an important role in this stress response.
      Title: Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice.
    3. These findings reveal a role for MOAP-1 in Fas signaling in the liver by promoting MTCH2-mediated tBid recruitment to mitochondria.
      Title: MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.
    4. MAP-1 is a direct mitochondrial target of Bax.
      Title: MAP-1 is a mitochondrial effector of Bax.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Gm20604

    Readthrough gene: Gm20604, Included gene: Gon7

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    modulator of apoptosis 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142937.2 → NP_001136409.1  modulator of apoptosis 1

      See identical proteins and their annotated locations for NP_001136409.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC132315, AU080670
      Consensus CDS
      CCDS26122.1
      UniProtKB/Swiss-Prot
      Q9ERH6
      Related
      ENSMUSP00000137010.2, ENSMUST00000178384.2
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 327
      PNMA

    2. NM_022323.7 → NP_071718.1  modulator of apoptosis 1

      See identical proteins and their annotated locations for NP_071718.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC132315, BU614788
      Consensus CDS
      CCDS26122.1
      UniProtKB/Swiss-Prot
      Q9ERH6
      Related
      ENSMUSP00000133459.3, ENSMUST00000173760.9
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 327
      PNMA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102706089..102709920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERH6.1 GenPept UniProtKB/Swiss-Prot:Q9ERH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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