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    Parvg parvin, gamma [ Mus musculus (house mouse) ]

    Gene ID: 64099, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Parvgprovided by MGI
    Official Full Name
    parvin, gammaprovided by MGI
    Primary source
    MGI:MGI:2158329
    See related
    Ensembl:ENSMUSG00000022439 AllianceGenome:MGI:2158329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in several processes, including actin cytoskeleton reorganization; cell projection assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in cell junction; cytoskeleton; and plasma membrane. Predicted to be active in actin cytoskeleton; cytoplasm; and focal adhesion. Is expressed in alimentary system; embryo mesenchyme; hemolymphoid system; liver; and thymus primordium. Orthologous to human PARVG (parvin gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 40.8), spleen adult (RPKM 24.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E2; 15 39.78 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84208388..84227179)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84324175..84342978)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33723 Neighboring gene parvin, beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84146147-84146300 Neighboring gene predicted gene, 22890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84185775-84185884 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84214597-84214798 Neighboring gene shisa like 1 Neighboring gene predicted gene, 46527

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response. Chu H, et al. Mol Cell Biol, 2006 Mar. PMID 16479001, Free PMC Article
    2. The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Thievessen I, et al. Curr Biol, 2022 Jul 25. PMID 35688156
    3. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. Korenbaum E, et al. Gene, 2001 Nov 14. PMID 11722847
    4. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. Olski TM, et al. J Cell Sci, 2001 Feb. PMID 11171322
    5. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Yogo K, et al. Endocrinology, 2006 Jul. PMID 16601135

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization.
      Title: Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans.
    2. despite the high expression of gamma-parvin in hematopoietic cells it must play a more subtle role for blood cell homeostasis
      Title: gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-parvin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162500.1 → NP_001155972.1  gamma-parvin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK079881, AL626769, BY200543
      Consensus CDS
      CCDS49686.1
      UniProtKB/TrEMBL
      E9PYG5, Q8C2K9, Q8CEF2
      Related
      ENSMUSP00000131443.2, ENSMUST00000163667.2
      Conserved Domains (1) summary
      pfam00307
      Location:265 → 365
      CH; Calponin homology (CH) domain

    2. NM_022321.4 → NP_071716.3  gamma-parvin isoform 2

      See identical proteins and their annotated locations for NP_071716.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK028329, AK079881, AL626769
      Consensus CDS
      CCDS27710.1
      UniProtKB/Swiss-Prot
      Q8BH45, Q91X89, Q9ERD8
      UniProtKB/TrEMBL
      Q8C2K9, Q8CEF2
      Related
      ENSMUSP00000023074.3, ENSMUST00000023074.9
      Conserved Domains (1) summary
      pfam00307
      Location:212 → 316
      CH; Calponin homology (CH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      84208388..84227179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245706.4 → XP_011244008.1  gamma-parvin isoform X1

      See identical proteins and their annotated locations for XP_011244008.1

      UniProtKB/Swiss-Prot
      Q8BH45, Q91X89, Q9ERD8
      UniProtKB/TrEMBL
      Q8C2K9, Q8CEF2
      Conserved Domains (1) summary
      pfam00307
      Location:212 → 316
      CH; Calponin homology (CH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERD8.2 GenPept UniProtKB/Swiss-Prot:Q9ERD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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