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    Ube4b ubiquitination factor E4B [ Mus musculus (house mouse) ]

    Gene ID: 63958, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ube4bprovided by MGI
    Official Full Name
    ubiquitination factor E4Bprovided by MGI
    Primary source
    MGI:MGI:1927086
    See related
    Ensembl:ENSMUSG00000028960 AllianceGenome:MGI:1927086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UFD2; UFD2a; Ufd2p; mKIAA0684; D4Bwg0973e; 4930551I19Rik; 4933406G05Rik
    Summary
    Enables ATP binding activity; enzyme binding activity; and ubiquitin-ubiquitin ligase activity. Acts upstream of or within several processes, including protein ubiquitination; ubiquitin-dependent protein catabolic process; and ventricular trabecula myocardium morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.6), cerebellum adult (RPKM 13.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 79.08 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149412873..149512618, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149328416..149428161, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12104 Neighboring gene STARR-positive B cell enhancer ABC_E3554 Neighboring gene phosphogluconate dehydrogenase Neighboring gene kinesin family member 1B Neighboring gene STARR-positive B cell enhancer ABC_E845 Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:148775428-148775611 Neighboring gene STARR-positive B cell enhancer ABC_E8033 Neighboring gene STARR-seq mESC enhancer starr_12112 Neighboring gene STARR-seq mESC enhancer starr_12113 Neighboring gene STARR-seq mESC enhancer starr_12114 Neighboring gene tRNA methyltransferase 11-2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_12115 Neighboring gene retinol binding protein 7, cellular Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrame protein 274

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. Susaki E, et al. J Biol Chem, 2010 May 14. PMID 20190229, Free PMC Article
    2. Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke. Jin S, et al. iScience, 2023 Jan 20. PMID 36654858, Free PMC Article
    3. Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo. Beirowski B, et al. J Neurosci, 2009 Jan 21. PMID 19158292, Free PMC Article
    4. The gene for slow Wallerian degeneration (Wld(s)) is also protective against vincristine neuropathy. Wang M, et al. Neurobiol Dis, 2001 Feb. PMID 11162249
    5. A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse. Conforti L, et al. Proc Natl Acad Sci U S A, 2000 Oct 10. PMID 11027338, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
      Title: Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.
    2. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.
      Title: A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.
    3. Characterization of the UFD2a gene.
      Title: Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a.
    4. UFD2a is essential for the development of cardiac muscle, as well as for the protection of spinocerebellar neurons from degeneration induced by endoplasmic reticulum stress.
      Title: Mammalian E4 is required for cardiac development and maintenance of the nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in granzyme-mediated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin conjugation factor E4 B
    Names
    RING-type E3 ubiquitin transferase E4 B
    ubiquitin fusion degradation protein 2
    ubiquitination factor E4B, UFD2 homolog
    NP_001391797.1
    NP_001391798.1
    NP_071305.2
    XP_006539151.1
    XP_036020184.1
    XP_036020185.1
    XP_036020187.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404868.1 → NP_001391797.1  ubiquitin conjugation factor E4 B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606973

    2. NM_001404869.1 → NP_001391798.1  ubiquitin conjugation factor E4 B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606973
      Related
      ENSMUSP00000158872.2, ENSMUST00000239095.2

    3. NM_022022.4 → NP_071305.2  ubiquitin conjugation factor E4 B isoform 1

      See identical proteins and their annotated locations for NP_071305.2

      Status: VALIDATED

      Source sequence(s)
      AL606973
      Consensus CDS
      CCDS18958.1
      UniProtKB/Swiss-Prot
      Q6DID4, Q9EQE0, Q9ES00
      UniProtKB/TrEMBL
      Q6NWW1
      Related
      ENSMUSP00000099501.4, ENSMUST00000103212.10
      Conserved Domains (2) summary
      pfam04564
      Location:1099 → 1169
      U-box; U-box domain
      pfam10408
      Location:462 → 1082
      Ufd2P_core; Ubiquitin elongating factor core

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149412873..149512618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539088.4 → XP_006539151.1  ubiquitin conjugation factor E4 B isoform X4

      UniProtKB/TrEMBL
      A0A571BD95
      Conserved Domains (3) summary
      PHA03307
      Location:275 → 522
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16658
      Location:1341 → 1415
      RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
      pfam10408
      Location:708 → 1328
      Ufd2P_core; Ubiquitin elongating factor core

    2. XM_036164292.1 → XP_036020185.1  ubiquitin conjugation factor E4 B isoform X3

      UniProtKB/TrEMBL
      A0A571BD95
      Conserved Domains (3) summary
      PHA03307
      Location:275 → 522
      PHA03307; transcriptional regulator ICP4; Provisional
      cd16658
      Location:1341 → 1399
      RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
      pfam10408
      Location:708 → 1328
      Ufd2P_core; Ubiquitin elongating factor core

    3. XM_036164291.1 → XP_036020184.1  ubiquitin conjugation factor E4 B isoform X2

      UniProtKB/TrEMBL
      A0A5F8MP95
      Conserved Domains (3) summary
      PHA03247
      Location:289 → 514
      PHA03247; large tegument protein UL36; Provisional
      cd16658
      Location:1380 → 1454
      RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
      pfam10408
      Location:747 → 1367
      Ufd2P_core; Ubiquitin elongating factor core

    4. XM_036164294.1 → XP_036020187.1  ubiquitin conjugation factor E4 B isoform X6

      Conserved Domains (2) summary
      cd16658
      Location:898 → 956
      RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
      pfam10408
      Location:265 → 885
      Ufd2P_core; Ubiquitin elongating factor core
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES00.3 GenPept UniProtKB/Swiss-Prot:Q9ES00

    Gene LinkOut

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