Impg1 interphotoreceptor matrix proteoglycan 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Impg1provided by MGI
Official Full Name: interphotoreceptor matrix proteoglycan 1provided by MGI
Primary source: MGI:MGI:1926876
See related: Ensembl:ENSMUSG00000032343 AllianceGenome:MGI:1926876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPACR; IMP150; A930015H12Rik
Summary: Predicted to enable heparin binding activity and hyaluronic acid binding activity. Acts upstream of or within extracellular matrix organization. Located in interphotoreceptor matrix. Human ortholog(s) of this gene implicated in retinitis pigmentosa and vitelliform macular dystrophy. Orthologous to human IMPG1 (interphotoreceptor matrix proteoglycan 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 E1; 9 43.99 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (80215467..80347707, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (80312773..80465654, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPACR Encoded by IMPG1 Is Essential for Photoreceptor Survival by Interplaying between the Interphotoreceptor Matrix and the Retinal Pigment Epithelium.
Title: SPACR Encoded by IMPG1 Is Essential for Photoreceptor Survival by Interplaying between the Interphotoreceptor Matrix and the Retinal Pigment Epithelium.
Murine orthologue of the human retinal glycoprotein IPM 150 (IMPG1), involved in retinal adhesion and photoreceptor cell survival. Analyses of IPM 150 and IPM 200 core proteins reveals the presence of multiple conserved domain of unknown function.
Title: Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa52b7.seq (e-PCR)
- UniSTS:125184

D9Mit343 (e-PCR), detects polymorphism
- UniSTS:131906

Impg1 (e-PCR), detects polymorphism
- UniSTS:186520

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in interphotoreceptor matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interphotoreceptor matrix proteoglycan 1

Names: IPM-150; interphotoreceptor matrix proteoglycan of 150 kDa; sialoprotein associated with cones and rods

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.