Sap30 sin3 associated polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sap30provided by MGI
Official Full Name: sin3 associated polypeptideprovided by MGI
Primary source: MGI:MGI:1929129
See related: Ensembl:ENSMUSG00000031609 AllianceGenome:MGI:1929129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 30kDa
Summary: Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including branchial arch; early embryo; embryo mesenchyme; forelimb bud; and sensory organ. Orthologous to human SAP30 (Sin3A associated protein 30). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 34.9), CNS E14 (RPKM 18.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B2; 8 29.85 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (57935740..57940874, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (57482702..57487860, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show using NMR that the mSin3A PAH3-SAP30 SID complex can bind to nucleic acids, hinting at a role for a nucleolar localization sequence in the SID alphaA helix in targeting the Rpd3L/Sin3L complex for silencing ribosomal RNA genes
Title: Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding.
Role in the establishment of NS interactions with host DNA sequences and Rift Valley fever virus (RVFV) pathogenesis.
Title: Nonstructural NSs protein of rift valley fever virus interacts with pericentromeric DNA sequences of the host cell, inducing chromosome cohesion and segregation defects.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in modulation by host of symbiont transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Sin3-type complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: histone deacetylase complex subunit SAP30

Names: 30 kDa Sin3-associated polypeptide; Sin3-associated protein; sin3 associated polypeptide, 30kD; sin3 corepressor complex subunit SAP30; sin3-associated polypeptide p30; sin3-associated polypeptide, 30 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021788.3 → NP_068560.1 histone deacetylase complex subunit SAP30

See identical proteins and their annotated locations for NP_068560.1

Status: VALIDATED

Source sequence(s)

AC130841

Consensus CDS

CCDS22316.1

UniProtKB/Swiss-Prot

A2RSE9, O88574, Q99JB9

Related

ENSMUSP00000034022.4, ENSMUST00000034022.4

Conserved Domains (2) summary

pfam13866
Location:65 → 133

zf-SAP30; SAP30 zinc-finger

pfam13867
Location:153 → 205

SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30