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    Zfp24 zinc finger protein 24 [ Mus musculus (house mouse) ]

    Gene ID: 59057, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfp24provided by MGI
    Official Full Name
    zinc finger protein 24provided by MGI
    Primary source
    MGI:MGI:1929704
    See related
    Ensembl:ENSMUSG00000051469 AllianceGenome:MGI:1929704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KOX17; ZF-12; Znf24; Zfp191; 3526401F17Rik; 5033419P20Rik
    Summary
    Enables sequence-specific DNA binding activity. Involved in myelination. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb primordium; and sensory organ. Orthologous to human ZNF24 (zinc finger protein 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.8), CNS E14 (RPKM 4.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 A2; 18 12.55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24142774..24155294, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (24009717..24020813, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene zinc finger protein 397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:24145637-24145876 Neighboring gene STARR-seq mESC enhancer starr_44051 Neighboring gene zinc finger protein 35 Neighboring gene STARR-positive B cell enhancer ABC_E8705 Neighboring gene STARR-seq mESC enhancer starr_44054 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44055 Neighboring gene predicted gene, 18085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation. Elbaz B, et al. Cell Rep, 2018 May 22. PMID 29791837, Free PMC Article
    2. Zinc finger protein 191 deficiency attenuates vascular smooth muscle cell proliferation, migration, and intimal hyperplasia after endovascular arterial injury. Lv L, et al. J Vasc Surg, 2014 Feb. PMID 23755975
    3. Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice. Sun RL, et al. Genet Mol Res, 2011 Dec 8. PMID 22183946
    4. Expression of the transcription factor Zfp191 during embryonic development in the mouse. Khalfallah O, et al. Gene Expr Patterns, 2008 Feb. PMID 18096443
    5. The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation. Li J, et al. Exp Cell Res, 2006 Dec 10. PMID 17064688

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFP24 binds to a consensus DNA sequence in proximity to genes important for oligodendrocyte differentiation.
      Title: Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation.
    2. ZFP191 played an essential role in aggressive proliferation and migration of vascular smooth muscle cells, which in turn facilitated intimal hyperplasia.
      Title: Zinc finger protein 191 deficiency attenuates vascular smooth muscle cell proliferation, migration, and intimal hyperplasia after endovascular arterial injury.
    3. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during lipopolysaccharide-induced endotoxic shock.
      Title: Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice.
    4. this study demonstrates that ZFP191 is required for the myelinating function of differentiated oligodendrocytes.
      Title: ZFP191 is required by oligodendrocytes for CNS myelination.
    5. Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage.
      Title: Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors.
    6. the DNA-binding domain of Zfp191 can specifically bind to the TCAT repeat motif, and there is a cooperative effect among the target DNA's multiple binding sites
      Title: Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191.
    7. These data show that Zfp191 is indispensable for early embryonic development and cell proliferation.
      Title: The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 24
    Names
    hypomyelinated CNS protein
    zfp-191
    zinc finger protein 191
    zinc finger protein ZF-12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357447.1 → NP_001344376.1  zinc finger protein 24

      Status: VALIDATED

      Source sequence(s)
      AC126807, BP764437
      Consensus CDS
      CCDS29098.1
      UniProtKB/Swiss-Prot
      Q5MDG8, Q91VN1, Q9WUQ0
      Conserved Domains (3) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001357448.1 → NP_001344377.1  zinc finger protein 24

      Status: VALIDATED

      Source sequence(s)
      AC126807, BP764437
      Consensus CDS
      CCDS29098.1
      UniProtKB/Swiss-Prot
      Q5MDG8, Q91VN1, Q9WUQ0
      Related
      ENSMUSP00000122579.2, ENSMUST00000153337.2
      Conserved Domains (3) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_021559.3 → NP_067534.2  zinc finger protein 24

      See identical proteins and their annotated locations for NP_067534.2

      Status: VALIDATED

      Source sequence(s)
      AC126807, BC054832, BP764437, CD562306
      Consensus CDS
      CCDS29098.1
      UniProtKB/Swiss-Prot
      Q5MDG8, Q91VN1, Q9WUQ0
      Related
      ENSMUSP00000064637.6, ENSMUST00000066497.12
      Conserved Domains (3) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      24142774..24155294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161225.1 → XP_036017118.1  zinc finger protein 24 isoform X1

      UniProtKB/Swiss-Prot
      Q5MDG8, Q91VN1, Q9WUQ0
      Conserved Domains (3) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036161226.1 → XP_036017119.1  zinc finger protein 24 isoform X1

      UniProtKB/Swiss-Prot
      Q5MDG8, Q91VN1, Q9WUQ0
      Conserved Domains (3) summary
      smart00431
      Location:48 → 159
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VN1.1 GenPept UniProtKB/Swiss-Prot:Q91VN1

    Gene LinkOut

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