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    Mettl9 methyltransferase like 9 [ Mus musculus (house mouse) ]

    Gene ID: 59052, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mettl9provided by MGI
    Official Full Name
    methyltransferase like 9provided by MGI
    Primary source
    MGI:MGI:1914862
    See related
    Ensembl:ENSMUSG00000030876 AllianceGenome:MGI:1914862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drev; mMETTL9; MNCb-5680; 0610012D09Rik
    Summary
    Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to act upstream of or within methylation. Predicted to be located in mitochondrion. Predicted to be active in endoplasmic reticulum. Is expressed in retina inner nuclear layer and retina outer nuclear layer. Orthologous to human METTL9 (methyltransferase like 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 36.9), CNS E14 (RPKM 28.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl9 in Genome Data Viewer
    Location:
    7 F2; 7 65.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120631717..120676058)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121032384..121076835)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene STARR-positive B cell enhancer ABC_E4973 Neighboring gene predicted pseudogene 9234 Neighboring gene predicted gene, 25924 Neighboring gene predicted gene, 27991 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene immunoglobulin superfamily, member 6 Neighboring gene otoancorin Neighboring gene STARR-seq mESC enhancer starr_20059 Neighboring gene src family associated phosphoprotein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Lv M, et al. Protein Cell, 2021 Dec. PMID 34218407, Free PMC Article
    2. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Davydova E, et al. Nat Commun, 2021 Feb 9. PMID 33563959, Free PMC Article
    3. siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9. Daitoku H, et al. J Biol Chem, 2021 Nov. PMID 34562450, Free PMC Article
    4. Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development. Shu KX, et al. Colloids Surf B Biointerfaces, 2006 Sep 1. PMID 16837177
    5. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. Bates EE, et al. Immunogenetics, 2000 Nov. PMID 11132146

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. siRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9.
      Title: siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9.
    2. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
      Title: The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-L-histidine N-pros-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-L-histidine N-pros-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-L-histidine N-pros-methyltransferase
    Names
    DORA reverse strand protein
    methyltransferase-like protein 9
    NP_001405493.1
    NP_001405494.1
    NP_001405495.1
    NP_001405496.1
    NP_001405497.1
    NP_001405498.1
    NP_001405499.1
    NP_001405500.1
    NP_001405501.1
    NP_001405502.1
    NP_001405503.1
    NP_001405504.1
    NP_001405505.1
    NP_001405506.1
    NP_001405507.1
    NP_001405508.1
    NP_001405509.1
    NP_001405510.1
    NP_001405511.1
    NP_001405512.1
    NP_067529.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418564.1 → NP_001405493.1  protein-L-histidine N-pros-methyltransferase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140782

    2. NM_001418565.1 → NP_001405494.1  protein-L-histidine N-pros-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140782

    3. NM_001418566.1 → NP_001405495.1  protein-L-histidine N-pros-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140782

    4. NM_001418567.1 → NP_001405496.1  protein-L-histidine N-pros-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140782

    5. NM_001418568.1 → NP_001405497.1  protein-L-histidine N-pros-methyltransferase isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140782

    6. NM_001418569.1 → NP_001405498.1  protein-L-histidine N-pros-methyltransferase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC140782

    7. NM_001418570.1 → NP_001405499.1  protein-L-histidine N-pros-methyltransferase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC140782

    8. NM_001418571.1 → NP_001405500.1  protein-L-histidine N-pros-methyltransferase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC140782

    9. NM_001418572.1 → NP_001405501.1  protein-L-histidine N-pros-methyltransferase isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140782

    10. NM_001418573.1 → NP_001405502.1  protein-L-histidine N-pros-methyltransferase isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140782

    11. NM_001418574.1 → NP_001405503.1  protein-L-histidine N-pros-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140782

    12. NM_001418575.1 → NP_001405504.1  protein-L-histidine N-pros-methyltransferase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC140782

    13. NM_001418576.1 → NP_001405505.1  protein-L-histidine N-pros-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140782
      Related
      ENSMUSP00000147071.2, ENSMUST00000207351.2

    14. NM_001418577.1 → NP_001405506.1  protein-L-histidine N-pros-methyltransferase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC140782

    15. NM_001418578.1 → NP_001405507.1  protein-L-histidine N-pros-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140782

    16. NM_001418579.1 → NP_001405508.1  protein-L-histidine N-pros-methyltransferase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC140782

    17. NM_001418580.1 → NP_001405509.1  protein-L-histidine N-pros-methyltransferase isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC140782

    18. NM_001418581.1 → NP_001405510.1  protein-L-histidine N-pros-methyltransferase isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC140782

    19. NM_001418582.1 → NP_001405511.1  protein-L-histidine N-pros-methyltransferase isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC140782

    20. NM_001418583.1 → NP_001405512.1  protein-L-histidine N-pros-methyltransferase isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC140782

    21. NM_021554.3 → NP_067529.2  protein-L-histidine N-pros-methyltransferase isoform 1 precursor

      See identical proteins and their annotated locations for NP_067529.2

      Status: VALIDATED

      Source sequence(s)
      AC140782
      Consensus CDS
      CCDS21800.1
      UniProtKB/Swiss-Prot
      A0JG25, Q3TDX0, Q641L4, Q8R567, Q9EPL3, Q9EPL4, Q9JJ88
      Related
      ENSMUSP00000033163.7, ENSMUST00000033163.8
      Conserved Domains (1) summary
      pfam05219
      Location:56 → 317
      DREV; DREV methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120631717..120676058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPL4.1 GenPept UniProtKB/Swiss-Prot:Q9EPL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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