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    Sqor sulfide quinone oxidoreductase [ Mus musculus (house mouse) ]

    Gene ID: 59010, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Sqorprovided by MGI
    Official Full Name
    sulfide quinone oxidoreductaseprovided by MGI
    Primary source
    MGI:MGI:1929899
    See related
    Ensembl:ENSMUSG00000005803 AllianceGenome:MGI:1929899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sqrdl; 0610039J17Rik; 4930557M22Rik
    Summary
    Predicted to enable FAD binding activity and sulfide:quinone oxidoreductase activity. Predicted to be involved in hydrogen sulfide metabolic process and sulfide oxidation, using sulfide:quinone oxidoreductase. Located in mitochondrial inner membrane. Orthologous to human SQOR (sulfide quinone oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 67.7), colon adult (RPKM 56.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E5; 2 60.67 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122607249..122651473)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122765327..122809553)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05562 Neighboring gene STARR-positive B cell enhancer ABC_E10136 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:122615227-122615418 Neighboring gene STARR-seq mESC enhancer starr_05563 Neighboring gene predicted gene, 34430 Neighboring gene STARR-seq mESC enhancer starr_05564 Neighboring gene predicted gene, 54147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sulfide catabolism ameliorates hypoxic brain injury. Marutani E, et al. Nat Commun, 2021 May 25. PMID 34035265, Free PMC Article
    2. Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS. Linden DR, et al. Br J Pharmacol, 2012 Apr. PMID 21950400, Free PMC Article
    3. SQR mediates therapeutic effects of H(2)S by targeting mitochondrial electron transport to induce mitochondrial uncoupling. Jia J, et al. Sci Adv, 2020 Aug. PMID 32923620, Free PMC Article
    4. The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria. Ackermann M, et al. Cell Tissue Res, 2014 Dec. PMID 25130143
    5. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulfide quinone oxidoreductase contributes to voltage sensing of the mitochondrial permeability transition pore.
      Title: Sulfide quinone oxidoreductase contributes to voltage sensing of the mitochondrial permeability transition pore.
    2. Sulfide catabolism ameliorates hypoxic brain injury.
      Title: Sulfide catabolism ameliorates hypoxic brain injury.
    3. The present report demonstrates the presence and specific localization of SQRDL in various mammalian tissues.
      Title: The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria.
    4. Levels of mRNA encoding SQR were higher in the colonic muscularis externa and the liver than in the brain.
      Title: Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione-dependent sulfide quinone oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfide:quinone oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfide:quinone oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfide oxidation, using sulfide:quinone oxidoreductase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfide oxidation, using sulfide:quinone oxidoreductase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sulfide:quinone oxidoreductase, mitochondrial
    Names
    flavo-binding protein
    sulfide quinone reductase-like
    NP_001155975.1
    NP_067482.4
    XP_006500029.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162503.1 → NP_001155975.1  sulfide:quinone oxidoreductase, mitochondrial

      See identical proteins and their annotated locations for NP_001155975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK075598, BP772838
      Consensus CDS
      CCDS16669.1
      UniProtKB/Swiss-Prot
      Q8BW20, Q91XA1, Q9D891, Q9R112
      UniProtKB/TrEMBL
      Q3UDS4
      Related
      ENSMUSP00000005953.5, ENSMUST00000005953.11
      Conserved Domains (1) summary
      COG0446
      Location:46 → 397
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    2. NM_021507.5 → NP_067482.4  sulfide:quinone oxidoreductase, mitochondrial

      See identical proteins and their annotated locations for NP_067482.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK075598, AL928950, BP772838
      Consensus CDS
      CCDS16669.1
      UniProtKB/Swiss-Prot
      Q8BW20, Q91XA1, Q9D891, Q9R112
      UniProtKB/TrEMBL
      Q3UDS4
      Related
      ENSMUSP00000106133.3, ENSMUST00000110506.9
      Conserved Domains (1) summary
      COG0446
      Location:46 → 397
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

    RNA

    1. NR_027888.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK075598, AL928950, BP772838

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      122607249..122651473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499966.3 → XP_006500029.1  sulfide:quinone oxidoreductase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006500029.1

      UniProtKB/Swiss-Prot
      Q8BW20, Q91XA1, Q9D891, Q9R112
      UniProtKB/TrEMBL
      Q3UDS4
      Conserved Domains (1) summary
      COG0446
      Location:46 → 397
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R112.3 GenPept UniProtKB/Swiss-Prot:Q9R112

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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