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    Anapc5 anaphase-promoting complex subunit 5 [ Mus musculus (house mouse) ]

    Gene ID: 59008, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Anapc5provided by MGI
    Official Full Name
    anaphase-promoting complex subunit 5provided by MGI
    Primary source
    MGI:MGI:1929722
    See related
    Ensembl:ENSMUSG00000029472 AllianceGenome:MGI:1929722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC5; Anpc5; 2510006G12Rik
    Summary
    Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 122.1), CNS E14 (RPKM 119.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 62.58 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122925522..122960402, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122787459..122822339, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14295 Neighboring gene predicted gene 10064 Neighboring gene purinergic receptor P2X, ligand-gated ion channel 4 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2, beta Neighboring gene STARR-positive B cell enhancer ABC_E3614 Neighboring gene STARR-seq mESC enhancer starr_14298 Neighboring gene STARR-positive B cell enhancer ABC_E10348 Neighboring gene STARR-positive B cell enhancer ABC_E1307 Neighboring gene STARR-positive B cell enhancer ABC_E2762 Neighboring gene predicted gene, 33044 Neighboring gene ring finger protein 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction. Ho AW, et al. PLoS One, 2013. PMID 23922952, Free PMC Article
    2. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. Sone M, et al. J Cell Sci, 2007 Aug 1. PMID 17623775
    3. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
    4. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.
      Title: The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 5
    Names
    cyclosome subunit 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042491.2 → NP_001035956.1  anaphase-promoting complex subunit 5 isoform b

      See identical proteins and their annotated locations for NP_001035956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC115728, BC046804, BP766822
      Consensus CDS
      CCDS80397.1
      UniProtKB/TrEMBL
      Q3TGH0, Q3TXL9, Q3UFC2
      Related
      ENSMUSP00000142922.2, ENSMUST00000200645.5
      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

    2. NM_001289517.1 → NP_001276446.1  anaphase-promoting complex subunit 5 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splices sites, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC115728, AK151314, AK159713, BP766822
      Consensus CDS
      CCDS80396.1
      UniProtKB/TrEMBL
      A0A0G2JE03, Q3U5Y4
      Related
      ENSMUSP00000142579.2, ENSMUST00000197719.5
      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

    3. NM_001289518.1 → NP_001276447.1  anaphase-promoting complex subunit 5 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC115728, AK151905, AK159713, BP766822
      Consensus CDS
      CCDS80400.1
      UniProtKB/TrEMBL
      A0A0G2JDM7, Q3U981
      Related
      ENSMUSP00000142429.2, ENSMUST00000196640.5
      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

    4. NM_001289519.1 → NP_001276448.1  anaphase-promoting complex subunit 5 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC115728, AK075969, AK151905, BP766822
      Consensus CDS
      CCDS80399.1
      UniProtKB/TrEMBL
      A0A0G2JDE8
      Related
      ENSMUSP00000142341.2, ENSMUST00000199406.5
      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

    5. NM_001289520.1 → NP_001276449.1  anaphase-promoting complex subunit 5 isoform f

      See identical proteins and their annotated locations for NP_001276449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
      Source sequence(s)
      AC115728, AK159713, BP766822
      Consensus CDS
      CCDS80398.1
      UniProtKB/TrEMBL
      Q3TGH0, Q3TWF7, Q3TXL9
      Related
      ENSMUSP00000143053.2, ENSMUST00000197074.5
      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

    6. NM_021505.3 → NP_067480.2  anaphase-promoting complex subunit 5 isoform a

      See identical proteins and their annotated locations for NP_067480.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC115728, AK159916, BP766822
      Consensus CDS
      CCDS39258.1
      UniProtKB/Swiss-Prot
      Q3TGA7, Q80UJ6, Q80W43, Q8BTZ4, Q8BWW7, Q8C0F7, Q9CRX0, Q9CSL1, Q9JJB8
      UniProtKB/TrEMBL
      Q3THU3
      Related
      ENSMUSP00000083393.5, ENSMUST00000086216.9
      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122925522..122960402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254742.1 → XP_030110602.1  anaphase-promoting complex subunit 5 isoform X1

      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5

    2. XM_006530429.4 → XP_006530492.1  anaphase-promoting complex subunit 5 isoform X2

      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5

    3. XM_030254743.2 → XP_030110603.1  anaphase-promoting complex subunit 5 isoform X4

      Conserved Domains (3) summary
      sd00016
      Location:233 → 267
      Apc5; TPR repeat [structural motif]
      cd16270
      Location:20 → 153
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:239 → 339
      ANAPC5; Anaphase-promoting complex subunit 5

    4. XM_036165394.1 → XP_036021287.1  anaphase-promoting complex subunit 5 isoform X5

      UniProtKB/TrEMBL
      Q3TXL9
      Conserved Domains (3) summary
      sd00016
      Location:107 → 141
      Apc5; TPR repeat [structural motif]
      cd16270
      Location:1 → 27
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:113 → 213
      ANAPC5; Anaphase-promoting complex subunit 5

    5. XM_036165393.1 → XP_036021286.1  anaphase-promoting complex subunit 5 isoform X3

      UniProtKB/TrEMBL
      Q3THU3
      Conserved Domains (3) summary
      sd00016
      Location:107 → 141
      Apc5; TPR repeat [structural motif]
      cd16270
      Location:1 → 27
      Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
      pfam12862
      Location:113 → 213
      ANAPC5; Anaphase-promoting complex subunit 5

    RNA

    1. XR_387575.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTZ4.1 GenPept UniProtKB/Swiss-Prot:Q8BTZ4

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