Gsdma gasdermin A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsdmaprovided by MGI
Official Full Name: gasdermin Aprovided by MGI
Primary source: MGI:MGI:1889509
See related: Ensembl:ENSMUSG00000017204 AllianceGenome:MGI:1889509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gsdm; Gsdm1; H312E; Gsdma1
Summary: Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in apoptotic process; defense response to bacterium; and pyroptosis. Predicted to act upstream of or within programmed cell death. Located in cytoplasm. Is expressed in esophagus epithelium; stomach; stomach cardiac region; stomach glandular region; and stomach glandular region mucosa. Orthologous to human GSDMA (gasdermin A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 18.5), testis adult (RPKM 2.8) and 1 other tissue See more
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Genomic context

Location:: 11 D; 11 62.34 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98555163..98568534)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98664337..98677708)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model.
Title: Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model.
CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis.
Title: CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ksks311 (e-PCR)
- UniSTS:514355

NoName (e-PCR)
- UniSTS:487991

BB149167 (e-PCR)
- UniSTS:185912

Gsdma1 (e-PCR), detects polymorphism
- UniSTS:525440

D11Mit197 (e-PCR), detects polymorphism
- UniSTS:126395

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables wide pore channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in pyroptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyroptosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gasdermin-A

Names: gasdermin 1; gasdermin-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021347.4 → NP_067322.1 gasdermin-A

See identical proteins and their annotated locations for NP_067322.1

Status: VALIDATED

Source sequence(s)

AK028698

Consensus CDS

CCDS25358.1

UniProtKB/Swiss-Prot

A3KFN3, Q9EST1

Related

ENSMUSP00000017348.3, ENSMUST00000017348.3

Conserved Domains (1) summary

pfam04598
Location:3 → 419

Gasdermin; Gasdermin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

98555163..98568534

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533850.1 → XP_006533913.1 gasdermin-A isoform X1

Conserved Domains (2) summary

pfam04598
Location:3 → 234

Gasdermin; Gasdermin family

pfam17708
Location:273 → 436

Gasdermin_C; Gasdermin PUB domain