Pglyrp2 peptidoglycan recognition protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pglyrp2provided by MGI
Official Full Name: peptidoglycan recognition protein 2provided by MGI
Primary source: MGI:MGI:1928099
See related: Ensembl:ENSMUSG00000079563 AllianceGenome:MGI:1928099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: tagL; PGRP-L; Pglyrpl; C730002N09Rik
Summary: Predicted to enable N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Acts upstream of or within several processes, including negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation involved in immune response; and regulation of inflammatory response. Predicted to be located in extracellular region and membrane. Is expressed in hemolymphoid system and thymus primordium. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 42.8), thymus adult (RPKM 34.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (32631433..32643157, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32412459..32424219, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFkappaB inflammatory axis in coronary artery disease.
Title: Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFκB inflammatory axis in coronary artery disease.
Study shows sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel role for Pglyrp2 as a key regulator of motor and anxiety-like behavior in late life.
Title: Sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 knockout mice.
Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice
Title: Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4.
Nod2(-/-) Pglyrp2(-/-) mice displayed increased susceptibility to infection at 24 h postinfection compared to Pglyrp2(-/-). Thus, PGLYRP2 plays a protective role in vivo in the control of S. Typhimurium infection through a Nod1/Nod2-independent mechanism.
Title: Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo.
Pglyrp2 limits overactivation of Th17 cells by promoting accumulation of regulatory T cells at the site of inflammation in an experimentally induced mouse model of psoriasis
Title: Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses.
role in regulation of the enteric host-microbe homeostasis
Title: Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes.
The authors demonstrate that PGLYRP-2 and Nod2 are both required for arthritis in the peptidoglycan-induced arthritis model in mice.
Title: PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation.
substantially impaired Listeria monocytogenes invasion and early intracellular growth in human epithelial cells. [TagL]
Title: Mammalian peptidoglycan recognition protein TagL inhibits Listeria monocytogenes invasion into epithelial cells.
In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi.
Title: Innate immune responses in peptidoglycan recognition protein L-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan immune receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan immune receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biological process involved in interaction with host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylmuramoyl-L-alanine amidase

Names: peptidoglycan recognition protein long

NP_001258405.1

EC 3.5.1.28

NP_001258406.1

EC 3.5.1.28

NP_001258407.1

EC 3.5.1.28

NP_001258408.1

EC 3.5.1.28

NP_067294.2

EC 3.5.1.28

XP_006524773.1

EC 3.5.1.28

XP_006524774.1

EC 3.5.1.28

XP_006524775.1

EC 3.5.1.28

XP_006524776.1

EC 3.5.1.28

XP_006524777.1

EC 3.5.1.28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271476.1 → NP_001258405.1 N-acetylmuramoyl-L-alanine amidase isoform a precursor

See identical proteins and their annotated locations for NP_001258405.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).

Source sequence(s)

AK039953, AY282722, CT485616

Consensus CDS

CCDS37557.1

UniProtKB/Swiss-Prot

Q8K4I8, Q8VCS0, Q9QXZ1, Q9QXZ2

UniProtKB/TrEMBL

Q54A77

Related

ENSMUSP00000158365.2, ENSMUST00000236386.2

Conserved Domains (1) summary

smart00701
Location:360 → 505

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_001271477.1 → NP_001258406.1 N-acetylmuramoyl-L-alanine amidase isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AK050019, CT485616

Consensus CDS

CCDS89066.1

UniProtKB/TrEMBL

A0A498WFR9

Related

ENSMUSP00000110099.3, ENSMUST00000114455.3

Conserved Domains (1) summary

cl02712
Location:360 → 421

PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
NM_001271478.1 → NP_001258407.1 N-acetylmuramoyl-L-alanine amidase isoform c precursor

See identical proteins and their annotated locations for NP_001258407.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c, also known as TagL-epsilon) is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AK039953, AY282722, CT485616

Consensus CDS

CCDS89065.1

UniProtKB/TrEMBL

Q71S36

Related

ENSMUSP00000157771.2, ENSMUST00000237130.2

Conserved Domains (1) summary

cl02712
Location:360 → 427

PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
NM_001271479.1 → NP_001258408.1 N-acetylmuramoyl-L-alanine amidase isoform d precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice site and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d, also known as TagL-delta) is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AY282722, CT485616

Consensus CDS

CCDS89067.1

UniProtKB/TrEMBL

A0A494B9M1, Q71S45

Related

ENSMUSP00000157711.2, ENSMUST00000237165.2
NM_021319.5 → NP_067294.2 N-acetylmuramoyl-L-alanine amidase isoform a precursor

See identical proteins and their annotated locations for NP_067294.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).

Source sequence(s)

AK050019, AY282722, CT485616

Consensus CDS

CCDS37557.1

UniProtKB/Swiss-Prot

Q8K4I8, Q8VCS0, Q9QXZ1, Q9QXZ2

UniProtKB/TrEMBL

Q54A77

Related

ENSMUSP00000129964.2, ENSMUST00000170392.9

Conserved Domains (1) summary

smart00701
Location:360 → 505

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RNA

NR_073184.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AY282722, CT485616

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

32631433..32643157 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524714.4 → XP_006524777.1 N-acetylmuramoyl-L-alanine amidase isoform X3

See identical proteins and their annotated locations for XP_006524777.1

UniProtKB/TrEMBL

Q71S36

Conserved Domains (1) summary

cl02712
Location:360 → 427

PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
XM_006524713.4 → XP_006524776.1 N-acetylmuramoyl-L-alanine amidase isoform X2

Conserved Domains (1) summary

cl02712
Location:360 → 421

PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
XM_006524712.4 → XP_006524775.1 N-acetylmuramoyl-L-alanine amidase isoform X1

See identical proteins and their annotated locations for XP_006524775.1

UniProtKB/TrEMBL

Q54A77

Conserved Domains (1) summary

smart00701
Location:360 → 505

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
XM_006524711.4 → XP_006524774.1 N-acetylmuramoyl-L-alanine amidase isoform X1

See identical proteins and their annotated locations for XP_006524774.1

UniProtKB/TrEMBL

Q54A77

Conserved Domains (1) summary

smart00701
Location:360 → 505

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
XM_006524710.4 → XP_006524773.1 N-acetylmuramoyl-L-alanine amidase isoform X1

See identical proteins and their annotated locations for XP_006524773.1

UniProtKB/TrEMBL

Q54A77

Conserved Domains (1) summary

smart00701
Location:360 → 505

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme