Isg20 interferon-stimulated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Isg20provided by MGI
Official Full Name: interferon-stimulated proteinprovided by MGI
Primary source: MGI:MGI:1928895
See related: Ensembl:ENSMUSG00000039236 AllianceGenome:MGI:1928895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 20kDa; DnaQL; HEM45; 1600023I01Rik; 2010107M23Rik
Summary: Predicted to enable 3'-5' exonuclease activity and RNA binding activity. Predicted to be involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Predicted to act upstream of or within innate immune response and rRNA processing. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be active in nucleus. Is expressed in liver lobe. Orthologous to human ISG20 (interferon stimulated exonuclease gene 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 49.6), testis adult (RPKM 49.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D2; 7 44.84 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (78561136..78570144)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (78913396..78920396)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury.
Title: Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury.
ISG20 upregulated IFIT1 genes and inhibited translation of the alphavirus genome. Furthermore, IFIT1-sensitive alphavirus replication was increased in Isg20(-/-) mice compared to the replication of wild-type viruses but not in cells ectopically expressing ISG20.
Title: The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.
Suggest that the recruitment of peripheral CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance.
Title: Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U1 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U2 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U3 snoRNA binding	ISO Inferred from Sequence Orthology more info
enables exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables exonuclease activity	ISO Inferred from Sequence Orthology more info
enables exoribonuclease II activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-stimulated gene 20 kDa protein

Names: interferon stimulated exonuclease; promyelocytic leukemia nuclear body-associated protein ISG20

NP_001106999.1

EC 3.1.13.1

NP_001278149.1

EC 3.1.13.1

NP_001278150.1

EC 3.1.13.1

NP_065608.2

EC 3.1.13.1

XP_006541089.1

EC 3.1.13.1

XP_006541091.1

EC 3.1.13.1

XP_030098687.1

EC 3.1.13.1

XP_036009174.1

EC 3.1.13.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113527.1 → NP_001106999.1 interferon-stimulated gene 20 kDa protein isoform b

See identical proteins and their annotated locations for NP_001106999.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).

Source sequence(s)

AK008139, AW122677

Consensus CDS

CCDS21376.1

UniProtKB/TrEMBL

Q3UW00, Q4FK39

Related

ENSMUSP00000113255.2, ENSMUST00000120331.4

Conserved Domains (1) summary

cl10012
Location:8 → 163

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
NM_001291220.1 → NP_001278149.1 interferon-stimulated gene 20 kDa protein isoform a

See identical proteins and their annotated locations for NP_001278149.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC138376, AF217484, BE951148

Consensus CDS

CCDS71982.1

UniProtKB/Swiss-Prot

Q9CPZ5, Q9JL16

Related

ENSMUSP00000112621.2, ENSMUST00000121645.8

Conserved Domains (1) summary

cl10012
Location:8 → 144

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
NM_001291221.1 → NP_001278150.1 interferon-stimulated gene 20 kDa protein isoform b

See identical proteins and their annotated locations for NP_001278150.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).

Source sequence(s)

AC138376, AK136756, BE951148

Consensus CDS

CCDS21376.1

UniProtKB/TrEMBL

Q3UW00, Q4FK39

Related

ENSMUSP00000112480.2, ENSMUST00000118867.8

Conserved Domains (1) summary

cl10012
Location:8 → 163

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
NM_020583.5 → NP_065608.2 interferon-stimulated gene 20 kDa protein isoform b

See identical proteins and their annotated locations for NP_065608.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).

Source sequence(s)

AK008353, AK136756, AW122677, BY087214, W97502

Consensus CDS

CCDS21376.1

UniProtKB/TrEMBL

Q3UW00, Q4FK39

Related

ENSMUSP00000040080.9, ENSMUST00000038142.15

Conserved Domains (1) summary

cl10012
Location:8 → 163

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

78561136..78570144

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242827.2 → XP_030098687.1 interferon-stimulated gene 20 kDa protein isoform X1

UniProtKB/Swiss-Prot

Q9CPZ5, Q9JL16

Conserved Domains (1) summary

cl10012
Location:8 → 144

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
XM_036153281.1 → XP_036009174.1 interferon-stimulated gene 20 kDa protein isoform X2

UniProtKB/TrEMBL

A0A0U1RP59

Conserved Domains (1) summary

cl10012
Location:8 → 145

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
XM_006541026.2 → XP_006541089.1 interferon-stimulated gene 20 kDa protein isoform X1

See identical proteins and their annotated locations for XP_006541089.1

UniProtKB/Swiss-Prot

Q9CPZ5, Q9JL16

Conserved Domains (1) summary

cl10012
Location:8 → 144

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
XM_006541028.5 → XP_006541091.1 interferon-stimulated gene 20 kDa protein isoform X1

See identical proteins and their annotated locations for XP_006541091.1

UniProtKB/Swiss-Prot

Q9CPZ5, Q9JL16

Conserved Domains (1) summary

cl10012
Location:8 → 144

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily