P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2ry4provided by MGI
Official Full Name: pyrimidinergic receptor P2Y, G-protein coupled, 4provided by MGI
Primary source: MGI:MGI:1926594
See related: Ensembl:ENSMUSG00000044359 AllianceGenome:MGI:1926594
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2Y4; P2Y4R
Summary: Enables G protein-coupled UTP receptor activity. Acts upstream of or within cellular response to prostaglandin E stimulus and transepithelial chloride transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Is expressed in skeletal muscle. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 7.1), large intestine adult (RPKM 3.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3; X 43.72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (99631964..99638533, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (100588358..100594927, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Central role of PD-L1 in cardioprotection resulting from P2Y4 nucleotide receptor loss.
Title: Central role of PD-L1 in cardioprotection resulting from P2Y(4) nucleotide receptor loss.
These data highlight the P2Y4 receptor as an inhibitor of cardiac fat formation
Title: Mouse P2Y(4) Nucleotide Receptor Is a Negative Regulator of Cardiac Adipose-Derived Stem Cell Differentiation and Cardiac Fat Formation.
In the brain samples, expressions of P2Y4 and P2X7 were significantly reduced, whereas that of P2Y1 was significantly elevated in an age-dependent manner.
Title: Viability of SH-SY5Y cells is associated with purinergic P2 receptor expression alterations.
Data show that activation of nucleotide receptor P2Y4 (P2Y4) in the differentiating embryonic stem cells (ESCs) resulted in an increased proportion of neurons expressing vesicular glutamate transporter (vGluT).
Title: P2Y4 Nucleotide Receptor in Neuronal Precursors Induces Glutamatergic Subtype Markers in Their Descendant Neurons.
present study defines the P2Y4 nucleotide receptor, expressed on cardiac microvascular endothelial cells and involved in postnatal heart development, as an important regulator of the inflammatory response to cardiac ischemia
Title: Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation.
Amyloid beta peptide 1-42 induced self-uptake in microglia through pinocytosis, a process involving activation of P2Y4 receptors by autocrine ATP signaling.
Title: P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia.
P2Y(4) receptor could constitute an important regulator of acute and chronic response to exercise.
Title: Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise.
study uncovers mouse P2Y(4) receptor as an essential regulator of cardiac endothelial cell function, and illustrates the involvement of endothelial-cardiomyocyte interactions in post-natal heart development
Title: P2Y(4) nucleotide receptor: a novel actor in post-natal cardiac development.
Purinergic receptors might represent important new set of molecular targets for theca hyperplasia and polycystic ovarian syndrome.
Title: Functional expression and intracellular signaling of UTP-sensitive P2Y receptors in theca-interstitial cells.
AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors.
Title: Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494961

px-56b9 (e-PCR)
- UniSTS:257929

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled UTP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UTP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables pyrimidine nucleotide binding	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to prostaglandin E stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transepithelial chloride transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: P2Y purinoceptor 4

Names: P2Y4 receptor; purinergic receptor P2Y, G-protein coupled, 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020621.4 → NP_065646.1 P2Y purinoceptor 4

See identical proteins and their annotated locations for NP_065646.1

Status: VALIDATED

Source sequence(s)

AL671299

Consensus CDS

CCDS30303.1

UniProtKB/Swiss-Prot

Q9JJS7

UniProtKB/TrEMBL

Q0VBT7

Related

ENSMUSP00000055869.2, ENSMUST00000053373.2

Conserved Domains (1) summary

cd15374
Location:32 → 313

7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

99631964..99638533 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528178.2 → XP_006528241.1 P2Y purinoceptor 4 isoform X1

See identical proteins and their annotated locations for XP_006528241.1

UniProtKB/Swiss-Prot

Q9JJS7

UniProtKB/TrEMBL

Q0VBT7

Conserved Domains (1) summary

cd15374
Location:32 → 313

7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006528175.2 → XP_006528238.1 P2Y purinoceptor 4 isoform X1

See identical proteins and their annotated locations for XP_006528238.1

UniProtKB/Swiss-Prot

Q9JJS7

UniProtKB/TrEMBL

Q0VBT7

Conserved Domains (1) summary

cd15374
Location:32 → 313

7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006528176.3 → XP_006528239.1 P2Y purinoceptor 4 isoform X1

See identical proteins and their annotated locations for XP_006528239.1

UniProtKB/Swiss-Prot

Q9JJS7

UniProtKB/TrEMBL

Q0VBT7

Conserved Domains (1) summary

cd15374
Location:32 → 313

7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006528177.2 → XP_006528240.1 P2Y purinoceptor 4 isoform X1

See identical proteins and their annotated locations for XP_006528240.1

UniProtKB/Swiss-Prot

Q9JJS7

UniProtKB/TrEMBL

Q0VBT7

Conserved Domains (1) summary

cd15374
Location:32 → 313

7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors