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    Ly6i lymphocyte antigen 6 family member I [ Mus musculus (house mouse) ]

    Gene ID: 57248, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ly6iprovided by MGI
    Official Full Name
    lymphocyte antigen 6 family member Iprovided by MGI
    Primary source
    MGI:MGI:1888480
    See related
    Ensembl:ENSMUSG00000022586 AllianceGenome:MGI:1888480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly-6I; Ly-6M
    Summary
    Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be located in membrane. Predicted to be anchored component of membrane. Predicted to be active in plasma membrane. Orthologous to human LY6H (lymphocyte antigen 6 family member H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 1.7), thymus adult (RPKM 1.2) and 14 other tissues See more
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    Genomic context

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    Location:
    15; 15 D3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74851383..74855279, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74979534..74983434, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1173 Neighboring gene predicted gene, 39556 Neighboring gene STARR-seq mESC enhancer starr_39002 Neighboring gene STARR-positive B cell enhancer ABC_E7383 Neighboring gene lymphocyte antigen 6 family member E Neighboring gene predicted gene 28068 Neighboring gene STARR-positive B cell enhancer ABC_E10863 Neighboring gene predicted gene 8000 Neighboring gene predicted gene, 41348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ly-6I, a new member of the murine Ly-6 superfamily with a distinct pattern of expression. Pflugh DL, et al. J Immunol, 2000 Jul 1. PMID 10861067
    2. Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins. Patterson JM, et al. Blood, 2000 May 15. PMID 10807778
    3. Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1. Stier MT, et al. Mamm Genome, 2012 Apr. PMID 22101863, Free PMC Article
    4. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte antigen 6I
    Names
    lymphocyte antigen 6 complex, locus I
    lymphocyte antigen 6M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358005.1 → NP_001344934.1  lymphocyte antigen 6I precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124637
      Consensus CDS
      CCDS27539.1
      UniProtKB/Swiss-Prot
      Q05AA4, Q9WU67
      UniProtKB/TrEMBL
      B7ZN85
      Related
      ENSMUSP00000129867.2, ENSMUST00000166694.2
      Conserved Domains (1) summary
      pfam00021
      Location:29 → 105
      UPAR_LY6; u-PAR/Ly-6 domain

    2. NM_020498.3 → NP_065244.2  lymphocyte antigen 6I precursor

      See identical proteins and their annotated locations for NP_065244.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124637
      Consensus CDS
      CCDS27539.1
      UniProtKB/Swiss-Prot
      Q05AA4, Q9WU67
      UniProtKB/TrEMBL
      B7ZN85
      Related
      ENSMUSP00000023250.5, ENSMUST00000023250.11
      Conserved Domains (1) summary
      pfam00021
      Location:29 → 105
      UPAR_LY6; u-PAR/Ly-6 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      74851383..74855279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WU67.1 GenPept UniProtKB/Swiss-Prot:Q9WU67

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