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    Mllt11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [ Mus musculus (house mouse) ]

    Gene ID: 56772, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mllt11provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11provided by MGI
    Primary source
    MGI:MGI:1929671
    See related
    Ensembl:ENSMUSG00000053192 AllianceGenome:MGI:1929671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Af1q; Zfp692
    Summary
    Predicted to be involved in several processes, including apoptotic signaling pathway; positive regulation of mitochondrial depolarization; and positive regulation of release of cytochrome c from mitochondria. Located in cytoplasm. Is expressed in several structures, including gut; liver; nervous system; secondary oocyte; and sensory organ. Orthologous to human MLLT11 (MLLT11 transcription factor 7 cofactor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 117.9), whole brain E14.5 (RPKM 86.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mllt11 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95125852..95139486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95218544..95229632, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells. Lin HJ, et al. Brain Res Mol Brain Res, 2004 Nov 24. PMID 15530661
    2. AF1q Contributes to Adriamycin-Induced Podocyte Injury by Activating Wnt/β-Catenin Signaling. Zhang H, et al. Kidney Blood Press Res, 2017. PMID 29069662
    3. MLLT11/AF1q is differentially expressed in maturing neurons during development. Yamada M, et al. Gene Expr Patterns, 2014 Jul. PMID 24839873
    4. Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11. Blommers M, et al. Dev Dyn, 2023 Feb. PMID 36131367
    5. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Stumpo DJ, et al. Blood, 2009 Sep 17. PMID 19633199, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11.
      Title: Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11.
    2. Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.
      Title: Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.
    3. aberrant expression of AF1q may activate Wnt/beta-catenin signaling and result in podocyte injury
      Title: AF1q Contributes to Adriamycin-Induced Podocyte Injury by Activating Wnt/β-Catenin Signaling.
    4. MLLT11 is a pan-neuronal marker, suggesting a role in neural differentiation in the central nervous system and neural crest-cell derived peripheral ganglia
      Title: MLLT11/AF1q is differentially expressed in maturing neurons during development.
    5. The mouse Af1q, homologue of human AF1q, was found to be significantly up-regulated during the neuronal production from neural stem cells
      Title: AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein AF1q
    Names
    ALL1-fused gene from chromosome 1q
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
    zinc finger protein 692

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411090.1 → NP_001398019.1  protein AF1q

      Status: VALIDATED

      Source sequence(s)
      AC140190
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0
      Related
      ENSMUSP00000143755.2, ENSMUST00000196025.5

    2. NM_001411091.1 → NP_001398020.1  protein AF1q

      Status: VALIDATED

      Source sequence(s)
      AC140190
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0

    3. NM_001411092.1 → NP_001398021.1  protein AF1q

      Status: VALIDATED

      Source sequence(s)
      AC140190
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0

    4. NM_019914.5 → NP_064298.1  protein AF1q

      See identical proteins and their annotated locations for NP_064298.1

      Status: VALIDATED

      Source sequence(s)
      AC140190
      Consensus CDS
      CCDS38544.1
      UniProtKB/Swiss-Prot
      P97783
      UniProtKB/TrEMBL
      Q543U0
      Related
      ENSMUSP00000066448.6, ENSMUST00000065482.6
      Conserved Domains (1) summary
      pfam15017
      Location:7 → 79
      WRNPLPNID; Putative WW-binding domain and destruction box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95125852..95139486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97783.1 GenPept UniProtKB/Swiss-Prot:P97783

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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