Tex101 testis expressed gene 101 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tex101provided by MGI
Official Full Name: testis expressed gene 101provided by MGI
Primary source: MGI:MGI:1930791
See related: Ensembl:ENSMUSG00000062773 AllianceGenome:MGI:1930791
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TES101RP; 1700008H15Rik
Summary: Involved in binding activity of sperm to zona pellucida; flagellated sperm motility; and regulation of flagellated sperm motility. Located in acrosomal membrane; extracellular region; and plasma membrane. Is anchored component of plasma membrane. Is expressed in genitourinary system and submandibular gland. Orthologous to human TEX101 (testis expressed 101). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 185.4) See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 12.13 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24367437..24371475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24668012..24672050, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization.
Title: Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization.
Role of the Glycosylphosphatidylinositol-Anchored Protein TEX101 and Its Related Molecules in Spermatogenesis.
Title: Role of the Glycosylphosphatidylinositol-Anchored Protein TEX101 and Its Related Molecules in Spermatogenesis.
Study demonstrated that both TEX101 and Ly6k contribute mutually for their protein expression in the testicular germ cells, suggesting that the expression-balance of these two proteins is essential for fertile sperm formation.
Title: TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells.
Tex101 knockout sperm lost the adhesive ability to the surface of female genital tract.
Title: Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice.
TEX101 is a unique specific substrate for ACE that is essential for the production of fertile mouse spermatozoa
Title: Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa.
NYD-SP8 has a role in regulating ECM degradation, providing a novel mechanism that modulates urokinase signalling in the suppression of cancer progression
Title: A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis.
DPEP3 forms complexes with Ts4-immunoreactive molecules, such as TEX101, on the surfaces of spermatocytes, spermatids, and testicular spermatozoa.
Title: Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis.
This study confirmed the biological interaction between TEX101 and Ly6k.
Title: TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis.
Deletion analysis of the chimeric structures indicated that sequences essential to gene expression should facilitate an understanding of the regulation of TEX101 expression during gametogenesis.
Title: Genomic organization and structure of the 5'-flanking region of the TEX101 gene: alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region.
From these results we concluded that cellubrevin-dependent membrane trafficking is involved in TEX101-transport to the surface of male germ cells.
Title: Testicular proteins associated with the germ cell-marker, TEX101: involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Tex101 (e-PCR), detects polymorphism
- UniSTS:507441

AI429076 (e-PCR)
- UniSTS:159613

AW557918 (e-PCR)
- UniSTS:208098

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in basophil activation	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: testis-expressed protein 101

Names: TES101-reactive protein; testis-expressed sequence 101 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.