Plag1 pleiomorphic adenoma gene 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plag1provided by MGI
Official Full Name: pleiomorphic adenoma gene 1provided by MGI
Primary source: MGI:MGI:1891916
See related: Ensembl:ENSMUSG00000003282 AllianceGenome:MGI:1891916
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; positive regulation of gene expression; and positive regulation of glial cell proliferation. Acts upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Is expressed in several structures, including brain; embryo ectoderm; genitourinary system; limb bud; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 2.3), CNS E11.5 (RPKM 1.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 2.18 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (3895209..3938429, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (3898769..3938430, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes.
Title: Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes.
Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis.
Title: Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis.
Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice.
Title: Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice.
Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development.
Title: Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development.
lncRNAs and mRNAs were differentially expressed in pleomorphic adenoma tissues obtained from PLAG1 transgenic mice as compared with those from control mice. These differentially expressed lncRNAs may act as novel biomarkers and therapeutic targets for pleomorphic adenoma.
Title: Dysregulated long non‑coding RNAs in pleomorphic adenoma tissues of pleomorphic adenoma gene 1 transgenic mice.
PLAG1 deficiency does not have a major impact on the reproductive control by the hypothalamo-pituitary system.
Title: PLAG1 expression and target genes in the hypothalamo-pituitary system in male mice.
Loss of PLAG1 resulted in significantly lowered daily sperm production, in reduced sperm motility, and in several animals, in sloughing of the germinal epithelium. The results demonstrate that the subfertility seen in male PLAG1-deficient mice is, at least in part, the result of significantly reduced sperm output and sperm motility.
Title: PLAG1 deficiency impairs spermatogenesis and sperm motility in mice.
Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances.
Title: Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.
Data indicate a plausible Plag1-Egr1-CD44 regulatory pathway in the T-ICs of pleomorphic adenomas.
Title: Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor.
results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt signaling
Title: Adenomyoepitheliomatous lesions of the mammary glands in transgenic mice with targeted PLAG1 overexpression.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Plag1 (e-PCR), detects polymorphism
- UniSTS:472870

NoName (e-PCR)
- UniSTS:548426

NoName (e-PCR)
- UniSTS:234861

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein PLAG1

Names: C2H2 zinc finger protein PLAG1; pleiomorphic adenoma gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019969.3 → NP_064353.2 zinc finger protein PLAG1

See identical proteins and their annotated locations for NP_064353.2

Status: VALIDATED

Source sequence(s)

AL807387, BC139283, CJ178210

Consensus CDS

CCDS17941.1

UniProtKB/Swiss-Prot

B1AXC4, Q3UXC0, Q9QYE0

Related

ENSMUSP00000003369.4, ENSMUST00000003369.10

Conserved Domains (3) summary

COG5189
Location:58 → 139

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:36 → 56

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:79 → 103

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

3895209..3938429 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538116.5 → XP_006538179.1 zinc finger protein PLAG1 isoform X1

See identical proteins and their annotated locations for XP_006538179.1

UniProtKB/Swiss-Prot

B1AXC4, Q3UXC0, Q9QYE0

Conserved Domains (3) summary

COG5189
Location:58 → 139

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:36 → 56

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:79 → 103

zf-H2C2_2; Zinc-finger double domain
XM_036164269.1 → XP_036020162.1 zinc finger protein PLAG1 isoform X1

UniProtKB/Swiss-Prot

B1AXC4, Q3UXC0, Q9QYE0

Conserved Domains (3) summary

COG5189
Location:58 → 139

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:36 → 56

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:79 → 103

zf-H2C2_2; Zinc-finger double domain
XM_006538122.5 → XP_006538185.1 zinc finger protein PLAG1 isoform X3

See identical proteins and their annotated locations for XP_006538185.1

Conserved Domains (3) summary

COG5236
Location:39 → 154

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:70 → 90

ZF_C2H2; C2H2 Zn finger [structural motif]

cd20908
Location:10 → 58

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
XM_036164273.1 → XP_036020166.1 zinc finger protein PLAG1 isoform X3

Conserved Domains (3) summary

COG5236
Location:39 → 154

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:70 → 90

ZF_C2H2; C2H2 Zn finger [structural motif]

cd20908
Location:10 → 58

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
XM_036164272.1 → XP_036020165.1 zinc finger protein PLAG1 isoform X3

Conserved Domains (3) summary

COG5236
Location:39 → 154

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:70 → 90

ZF_C2H2; C2H2 Zn finger [structural motif]

cd20908
Location:10 → 58

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
XM_036164271.1 → XP_036020164.1 zinc finger protein PLAG1 isoform X2

Conserved Domains (3) summary

COG5236
Location:41 → 156

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:72 → 92

ZF_C2H2; C2H2 Zn finger [structural motif]

cd20908
Location:12 → 60

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
XM_017320331.3 → XP_017175820.1 zinc finger protein PLAG1 isoform X1

UniProtKB/Swiss-Prot

B1AXC4, Q3UXC0, Q9QYE0

Conserved Domains (3) summary

COG5189
Location:58 → 139

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:36 → 56

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:79 → 103

zf-H2C2_2; Zinc-finger double domain
XM_036164270.1 → XP_036020163.1 zinc finger protein PLAG1 isoform X1

UniProtKB/Swiss-Prot

B1AXC4, Q3UXC0, Q9QYE0

Conserved Domains (3) summary

COG5189
Location:58 → 139

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:36 → 56

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:79 → 103

zf-H2C2_2; Zinc-finger double domain