Ranbp9 RAN binding protein 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ranbp9provided by MGI
Official Full Name: RAN binding protein 9provided by MGI
Primary source: MGI:MGI:1928741
See related: Ensembl:ENSMUSG00000038546 AllianceGenome:MGI:1928741
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ibap1; IBAP-1; RanBPM
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in cell surface receptor signaling pathway; cytoskeleton organization; and negative regulation of ERK1 and ERK2 cascade. Located in cytoplasm. Is expressed in palatal shelf. Orthologous to human RANBP9 (RAN binding protein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 40.0), adrenal adult (RPKM 14.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A4; 13 21.6 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (43556151..43634949, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (43402673..43481283, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lipopolysaccharide-Induced Acute Lung Injury Is Associated with Increased Ran-Binding Protein in Microtubule-Organizing Center (RanBPM) Molecule Expression and Mitochondria-Mediated Apoptosis Signaling Pathway in a Mouse Model.
Title: Lipopolysaccharide-Induced Acute Lung Injury Is Associated with Increased Ran-Binding Protein in Microtubule-Organizing Center (RanBPM) Molecule Expression and Mitochondria-Mediated Apoptosis Signaling Pathway in a Mouse Model.
Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin.
Title: Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin.
this study shows that RanBPM regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells
Title: RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells.
Results showed that RANBP9 is involved in alternative splicing by interacting with CLOCK during murine spermatogenesis.
Title: CLOCK interacts with RANBP9 and is involved in alternative splicing in spermatogenesis.
the role of RanBP9 in the brain
Title: RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice.
A novel role of Ranbp9 in regulating alternative splicing in spermatogenic cells, which is critical for normal spermatogenesis and male fertility.
Title: RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility.
The B-cell antigen receptor integrates adaptive and innate immune signals.
Title: The B-cell antigen receptor integrates adaptive and innate immune signals.
Data found that endogenous RanBP9 positively regulates SSH1 levels and mediates Abeta-induced translocation of cofilin to mitochondria and induction of cofilin-actin pathology in cultured cells, primary neurons, and in vivo
Title: RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction.
RanBP9 overexpression in APDeltaE9 mouse model of Alzheimer's disease further exacerbated the reductions in spine density in both the cortex and the hippocampus
Title: RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease.
results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
Title: Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EST8F3 (e-PCR)
- UniSTS:263432

RH133329 (e-PCR)
- UniSTS:216612

BB124184 (e-PCR)
- UniSTS:185972

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ran-binding protein 9

Names: B cell antigen receptor Ig beta associated protein 1; ran-binding protein M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404648.1 → NP_001391577.1 ran-binding protein 9 isoform 2

Status: VALIDATED

Source sequence(s)

AC132121

Related

ENSMUSP00000152620.2, ENSMUST00000222651.2
NM_019930.3 → NP_064314.2 ran-binding protein 9 isoform 1

Status: VALIDATED

Source sequence(s)

AC132121

Consensus CDS

CCDS49252.1

UniProtKB/Swiss-Prot

P69566, P84500, Q3V136

UniProtKB/TrEMBL

E9Q5D6

Related

ENSMUSP00000130636.2, ENSMUST00000144326.4

Conserved Domains (5) summary

smart00667
Location:346 → 379

LisH; Lissencephaly type-1-like homology motif

smart00668
Location:385 → 441

CTLH; C-terminal to LisH motif

smart00757
Location:597 → 698

CRA; CT11-RanBPM

pfam10607
Location:385 → 439

CLTH; CTLH/CRA C-terminal to LisH motif domain

cd12909
Location:171 → 313

SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10