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    Cdc42ep4 CDC42 effector protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 56699, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cdc42ep4provided by MGI
    Official Full Name
    CDC42 effector protein 4provided by MGI
    Primary source
    MGI:MGI:1929760
    See related
    Ensembl:ENSMUSG00000041598 AllianceGenome:MGI:1929760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CEP4; Borg4; 1500041M20Rik
    Summary
    Acts upstream of or within Rho protein signal transduction and cellular response to interferon-gamma. Located in phagocytic vesicle. Is expressed in several structures, including central nervous system; forelimb bud; lung; retina; and vibrissa. Orthologous to human CDC42EP4 (CDC42 effector protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 59.8), lung adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 79.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113617676..113643369, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113726850..113752543, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene STARR-seq mESC enhancer starr_31100 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene STARR-seq mESC enhancer starr_31103 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like Neighboring gene STARR-positive B cell enhancer ABC_E8469 Neighboring gene STARR-seq mESC enhancer starr_31107 Neighboring gene VISTA enhancer mm1462 Neighboring gene predicted gene 11736 Neighboring gene predicted gene, 39468 Neighboring gene sidekick cell adhesion molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of dendrite growth by Cdc42 effector protein‑4 in hippocampal neurons in vitro. Hou L, et al. Mol Med Rep, 2022 Apr. PMID 35169866, Free PMC Article
    2. CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration. Ageta-Ishihara N, et al. Neurochem Int, 2018 Oct. PMID 29330091
    3. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Ageta-Ishihara N, et al. Nat Commun, 2015 Dec 10. PMID 26657011, Free PMC Article
    4. Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue. Osada N, et al. J Hum Genet, 2000. PMID 11185749
    5. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. Kandi R, et al. EMBO Rep, 2021 Dec 6. PMID 34661963, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of dendrite growth by Cdc42 effector protein4 in hippocampal neurons in vitro.
      Title: Regulation of dendrite growth by Cdc42 effector protein‑4 in hippocampal neurons in vitro.
    2. overexpression of CDC42EP4 in heterologous cells promotes cell spreading and partitioning of MYH10 to insoluble (i.e., active) fraction
      Title: CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
    3. This study suggests propose that the CDC42EP4/septin-based glial scaffold facilitates perisynaptic localization of GLAST and optimizes the efficiency of glutamate-buffering and clearance.
      Title: A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cdc42 effector protein 4
    Names
    CDC42 effector protein (Rho GTPase binding) 4
    binder of Rho GTPase 4
    binder of Rho GTPases 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163346.1 → NP_001156818.1  cdc42 effector protein 4

      See identical proteins and their annotated locations for NP_001156818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB035088, AK165318
      Consensus CDS
      CCDS25604.1
      UniProtKB/Swiss-Prot
      Q3TNF3, Q9JM96, Q9QZT8
      UniProtKB/TrEMBL
      Q3TH99
      Related
      ENSMUSP00000060227.5, ENSMUST00000053536.5
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 79
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    2. NM_020006.2 → NP_064390.1  cdc42 effector protein 4

      See identical proteins and their annotated locations for NP_064390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB035088, AK075739, BM950172
      Consensus CDS
      CCDS25604.1
      UniProtKB/Swiss-Prot
      Q3TNF3, Q9JM96, Q9QZT8
      UniProtKB/TrEMBL
      Q3TH99
      Related
      ENSMUSP00000102227.2, ENSMUST00000106616.2
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 79
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      113617676..113643369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533815.2 → XP_006533878.1  cdc42 effector protein 4 isoform X1

      UniProtKB/TrEMBL
      Q3TH99
      Conserved Domains (2) summary
      pfam00786
      Location:111 → 164
      PBD; P21-Rho-binding domain
      pfam14957
      Location:195 → 304
      BORG_CEP; Cdc42 effector

    2. XM_006533817.3 → XP_006533880.1  cdc42 effector protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006533880.1

      UniProtKB/Swiss-Prot
      Q3TNF3, Q9JM96, Q9QZT8
      UniProtKB/TrEMBL
      Q3TH99
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 79
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    3. XM_017314686.3 → XP_017170175.1  cdc42 effector protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q3TNF3, Q9JM96, Q9QZT8
      UniProtKB/TrEMBL
      Q3TH99
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 79
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    4. XM_006533819.4 → XP_006533882.1  cdc42 effector protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006533882.1

      UniProtKB/Swiss-Prot
      Q3TNF3, Q9JM96, Q9QZT8
      UniProtKB/TrEMBL
      Q3TH99
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 79
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector

    5. XM_006533818.4 → XP_006533881.1  cdc42 effector protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006533881.1

      UniProtKB/Swiss-Prot
      Q3TNF3, Q9JM96, Q9QZT8
      UniProtKB/TrEMBL
      Q3TH99
      Conserved Domains (2) summary
      pfam00786
      Location:26 → 79
      PBD; P21-Rho-binding domain
      pfam14957
      Location:110 → 219
      BORG_CEP; Cdc42 effector
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JM96.1 GenPept UniProtKB/Swiss-Prot:Q9JM96

    Gene LinkOut

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