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    Akap10 A kinase anchor protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 56697, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Akap10provided by MGI
    Official Full Name
    A kinase anchor protein 10provided by MGI
    Primary source
    MGI:MGI:1890218
    See related
    Ensembl:ENSMUSG00000047804 AllianceGenome:MGI:1890218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRKA10; D-AKAP2; D-AKAP-2; 1500031L16Rik; B130049N18Rik
    Summary
    This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.1), frontal lobe adult (RPKM 3.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B2; 11 37.96 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61756029..61821134, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61865203..61930308, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene unc-51 like kinase 2 Neighboring gene STARR-seq mESC enhancer starr_29688 Neighboring gene STARR-seq mESC enhancer starr_29689 Neighboring gene STARR-positive B cell enhancer ABC_E8413 Neighboring gene predicted gene, 23721 Neighboring gene predicted gene 12273

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Burns LL, et al. Biochemistry, 2003 May 20. PMID 12741833
    2. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Tingley WG, et al. Proc Natl Acad Sci U S A, 2007 May 15. PMID 17485678, Free PMC Article
    3. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Burns-Hamuro LL, et al. Protein Sci, 2005 Dec. PMID 16260760, Free PMC Article
    4. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Gisler SM, et al. Kidney Int, 2003 Nov. PMID 14531807
    5. Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). Hamuro Y, et al. J Mol Biol, 2002 Aug 23. PMID 12206784

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein
      Title: Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS).
    2. D-AKAP2 may play an important role in the parathyroid hormone (PTH)-mediated regulation of NaPi-IIa by compartmentalization of PKA.
      Title: PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells.
    3. These studies suggest a role for AKAP10 in heart rhythm control.
      Title: Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 10, mitochondrial
    Names
    A kinase (PRKA) anchor protein 10
    dual specificity A kinase-anchoring protein 2
    protein kinase A-anchoring protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019921.3 → NP_064305.2  A-kinase anchor protein 10, mitochondrial precursor

      See identical proteins and their annotated locations for NP_064305.2

      Status: REVIEWED

      Source sequence(s)
      AK049399, AL646042
      Consensus CDS
      CCDS24821.1
      UniProtKB/Swiss-Prot
      O88845, Q5SUB5, Q5SUB7, Q7TPE7, Q8BQL6
      Related
      ENSMUSP00000099710.4, ENSMUST00000102650.10
      Conserved Domains (3) summary
      cd08721
      Location:383 → 503
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:122 → 367
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:618 → 662
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61756029..61821134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533814.5 → XP_006533877.1  A-kinase anchor protein 10, mitochondrial isoform X1

      Conserved Domains (3) summary
      cd08721
      Location:354 → 474
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:93 → 338
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:589 → 633
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

    RNA

    1. XR_879723.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88845.3 GenPept UniProtKB/Swiss-Prot:O88845

    Gene LinkOut

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