Mlycd malonyl-CoA decarboxylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mlycdprovided by MGI
Official Full Name: malonyl-CoA decarboxylaseprovided by MGI
Primary source: MGI:MGI:1928485
See related: Ensembl:ENSMUSG00000074064 AllianceGenome:MGI:1928485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcd
Summary: Enables malonyl-CoA decarboxylase activity. Involved in malonyl-CoA catabolic process and positive regulation of fatty acid oxidation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; nose; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in cardiomyopathy. Orthologous to human MLYCD (malonyl-CoA decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 29.4), liver adult (RPKM 25.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 67.64 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120121591..120148577)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119394852..119421838)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased fat oxidation in MCD(-/-) mice resulted in the accumulation of lipid intermediates in peripheral tissues, but this was not associated with a worsening of age-associated insulin resistance and, conversely, improved longevity.
Title: Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.
MCD(-/-) mice consistently exhibited cardiac dysfunction and severe metabolic perturbations while on a high-fat, low carbohydrate diet of maternal milk and these gradually resolved post-weaning.
Title: Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.
Data indicate that a full-dosage of p53 and an intact ribosomal protein-murine double minute 2 protein (Mdm2)-p53 pathway are required for the induction of malonyl coA decarboxylase (MCD), a critical regulator of fatty acid oxidation.
Title: Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.
SIRT4 deacetylates and represses malonyl CoA decarboxylase, regulating malonyl coA levels.
Title: SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
This study of fatty acid oxidation and malonyl-CoA decarboxylase identifies a critical role for metabolism in both the normal pulmonary circulation (hypoxic pulmonary vasoconstriction) and pulmonary hypertension
Title: Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.
Mcd deficiency is not detrimental to the heart in obesity in mice.
Title: Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
In vivo and ex vivo cardiac function is similar in wild-type and mcd-deficient mice; however, deletion of MCD markedly increases glucose oxidation and improves functional recovery of the heart after ischemia.
Title: Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

D8Mit188 (e-PCR), detects polymorphism
- UniSTS:131396

Mlycd (e-PCR), detects polymorphism
- UniSTS:516513

AI324784 (e-PCR)
- UniSTS:165602

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables malonyl-CoA decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables malonyl-CoA decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables malonyl-CoA decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malonyl-CoA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in malonyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malonyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: malonyl-CoA decarboxylase, mitochondrial

NP_001351257.1

EC 4.1.1.9

NP_064350.2

EC 4.1.1.9

XP_006531281.1

EC 4.1.1.9

XP_006531285.1

EC 4.1.1.9

XP_006531288.1

EC 4.1.1.9

XP_006531289.1

EC 4.1.1.9

XP_011246759.1

EC 4.1.1.9

XP_017168411.1

EC 4.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364328.1 → NP_001351257.1 malonyl-CoA decarboxylase, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AC166781

Conserved Domains (1) summary

pfam05292
Location:94 → 365

MCD; Malonyl-CoA decarboxylase (MCD)
NM_019966.3 → NP_064350.2 malonyl-CoA decarboxylase, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_064350.2

Status: VALIDATED

Source sequence(s)

AC166781

Consensus CDS

CCDS22703.1

UniProtKB/Swiss-Prot

Q7TNL6, Q99J39

Related

ENSMUSP00000095970.5, ENSMUST00000098367.5

Conserved Domains (1) summary

pfam05292
Location:94 → 455

MCD; Malonyl-CoA decarboxylase (MCD)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

120121591..120148577

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248457.4 → XP_011246759.1 malonyl-CoA decarboxylase, mitochondrial isoform X2

Conserved Domains (2) summary

pfam05292
Location:192 → 315

MCD; Malonyl-CoA decarboxylase C-terminal domain

pfam17408
Location:94 → 189

MCD_N; Malonyl-CoA decarboxylase N-terminal domain
XM_017312922.3 → XP_017168411.1 malonyl-CoA decarboxylase, mitochondrial isoform X4

Conserved Domains (2) summary

pfam05292
Location:192 → 315

MCD; Malonyl-CoA decarboxylase C-terminal domain

pfam17408
Location:94 → 189

MCD_N; Malonyl-CoA decarboxylase N-terminal domain
XM_006531222.5 → XP_006531285.1 malonyl-CoA decarboxylase, mitochondrial isoform X3

Conserved Domains (2) summary

pfam05292
Location:192 → 315

MCD; Malonyl-CoA decarboxylase C-terminal domain

pfam17408
Location:94 → 189

MCD_N; Malonyl-CoA decarboxylase N-terminal domain
XM_006531225.5 → XP_006531288.1 malonyl-CoA decarboxylase, mitochondrial isoform X5

Conserved Domains (2) summary

pfam05292
Location:192 → 315

MCD; Malonyl-CoA decarboxylase C-terminal domain

pfam17408
Location:94 → 189

MCD_N; Malonyl-CoA decarboxylase N-terminal domain
XM_006531226.5 → XP_006531289.1 malonyl-CoA decarboxylase, mitochondrial isoform X6

Conserved Domains (2) summary

pfam05292
Location:192 → 316

MCD; Malonyl-CoA decarboxylase C-terminal domain

pfam17408
Location:94 → 189

MCD_N; Malonyl-CoA decarboxylase N-terminal domain
XM_006531218.5 → XP_006531281.1 malonyl-CoA decarboxylase, mitochondrial isoform X1

Conserved Domains (2) summary

pfam05292
Location:174 → 437

MCD; Malonyl-CoA decarboxylase C-terminal domain

pfam17408
Location:105 → 171

MCD_N; Malonyl-CoA decarboxylase N-terminal domain