Adam21 a disintegrin and metallopeptidase domain 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam21provided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 21provided by MGI
Primary source: MGI:MGI:1861229
See related: Ensembl:ENSMUSG00000008438 AllianceGenome:MGI:1861229
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adam31
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. The encoded protein functions in the regulation of spermatogenesis in the testes and neurogenesis in the central nervous system. [provided by RefSeq, May 2016]
Expression: Biased expression in testis adult (RPKM 5.4) and cerebellum adult (RPKM 0.3) See more
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Genomic context

Location:: 12 D1; 12 37.79 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (81605349..81615248, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (81558575..81568474, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adam21 gene produces two types of transcripts with different cellular localization in the mouse testis, and the production of these alternate transcripts is due to utilization of cell-type-specific promoters.
Title: Expression analysis of the Adam21 gene in mouse testis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236900

Adam21 (e-PCR), detects polymorphism
- UniSTS:496841

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm head plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 21

Names: a disintegrin and metalloprotease domain (ADAM) 21; disintegrin and metalloproteinase domain-containing protein 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020330.5 → NP_065063.1 disintegrin and metalloproteinase domain-containing protein 21 preproprotein

See identical proteins and their annotated locations for NP_065063.1

Status: REVIEWED

Source sequence(s)

AK014827, AV268091

Consensus CDS

CCDS26022.1

UniProtKB/Swiss-Prot

A2RSL1, Q9JI76

Related

ENSMUSP00000008582.4, ENSMUST00000008582.4

Conserved Domains (5) summary

smart00608
Location:495 → 631

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:212 → 400

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:419 → 491

Disintegrin; Disintegrin

pfam01421
Location:213 → 402

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:55 → 163

Pep_M12B_propep; Reprolysin family propeptide