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    Txn2 thioredoxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 56551, updated on 21-Apr-2024

    Summary

    Official Symbol
    Txn2provided by MGI
    Official Full Name
    thioredoxin 2provided by MGI
    Primary source
    MGI:MGI:1929468
    See related
    Ensembl:ENSMUSG00000005354 AllianceGenome:MGI:1929468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trx2; 2510006J11Rik
    Summary
    Predicted to contribute to peptide-methionine (R)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity; and protein-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Located in mitochondrion. Is expressed in future spinal cord; spinal cord; and spinal cord white matter. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 463.2), duodenum adult (RPKM 177.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    15 E1; 15 36.92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77799251..77813194, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77915051..77928994, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 9, non-muscle Neighboring gene STARR-positive B cell enhancer ABC_E140 Neighboring gene STARR-positive B cell enhancer ABC_E5493 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:77680033-77680254 Neighboring gene STARR-seq mESC enhancer starr_39123 Neighboring gene predicted gene, 22107 Neighboring gene predicted gene, 53901 Neighboring gene STARR-seq mESC enhancer starr_39132 Neighboring gene STARR-positive B cell enhancer ABC_E479 Neighboring gene FAD-dependent oxidoreductase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3146 Neighboring gene eukaryotic translation initiation factor 3, subunit D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thioredoxin, mitochondrial
    Names
    MTRX
    mt-Trx
    thioredoxin nuclear gene encoding mitochondrial protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019913.5NP_064297.1  thioredoxin, mitochondrial precursor

      See identical proteins and their annotated locations for NP_064297.1

      Status: PROVISIONAL

      Source sequence(s)
      AL583886
      Consensus CDS
      CCDS27606.1
      UniProtKB/Swiss-Prot
      A2A440, P97493, Q545D5
      Related
      ENSMUSP00000005487.6, ENSMUST00000005487.12
      Conserved Domains (1) summary
      cd02947
      Location:72162
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      77799251..77813194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)