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    Sec1 secretory blood group 1 [ Mus musculus (house mouse) ]

    Gene ID: 56546, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sec1provided by MGI
    Official Full Name
    secretory blood group 1provided by MGI
    Primary source
    MGI:MGI:1928893
    See related
    Ensembl:ENSMUSG00000040364 AllianceGenome:MGI:1928893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fut3; Fut10
    Summary
    This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. This gene is predicted to encode a type II membrane protein, which is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in testis adult (RPKM 22.6), colon adult (RPKM 8.4) and 4 other tissues See more
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    Genomic context

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    Location:
    7 B3; 7 29.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45327110..45343825, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45677686..45694402, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene netrin 5 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene carbonic anhydrase 11 Neighboring gene D site albumin promoter binding protein Neighboring gene sphingosine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota. Ren Z, et al. Genes (Basel), 2022 Oct 14. PMID 36292744, Free PMC Article
    2. Insight into mechanisms of pig lncRNA FUT3-AS1 regulating E. coli F18-bacterial diarrhea. Wu Z, et al. PLoS Pathog, 2022 Jun. PMID 35696408, Free PMC Article
    3. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Esposito M, et al. Nat Cell Biol, 2019 May. PMID 30988423, Free PMC Article
    4. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. Baboval T, et al. Mamm Genome, 2002 Sep. PMID 12370785
    5. GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide. Lin B, et al. Biochim Biophys Acta, 2000 Sep 27. PMID 11018479

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.
      Title: Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.
    2. Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota.
      Title: Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota.
    3. E-selectin binding activity mediated by the alpha1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis. These findings provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone.
      Title: Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis.
    4. amino acid sequence and expression
      Title: Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactoside 2-alpha-L-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactoside 2-alpha-L-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galactoside 2-alpha-L-fucosyltransferase Sec1
    Names
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III
    alpha(1,2)FT 3
    fucosyltransferase 10
    galactoside 2-alpha-L-fucosyltransferase 3
    NP_001258507.1
    NP_001392824.1
    XP_006541073.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271578.2 → NP_001258507.1  galactoside 2-alpha-L-fucosyltransferase Sec1

      See identical proteins and their annotated locations for NP_001258507.1

      Status: VALIDATED

      Source sequence(s)
      AC167242
      Consensus CDS
      CCDS71963.1
      UniProtKB/TrEMBL
      Q496T8, Q8CDC9
      Related
      ENSMUSP00000045229.7, ENSMUST00000040636.9
      Conserved Domains (1) summary
      pfam01531
      Location:55 → 362
      Glyco_transf_11; Glycosyl transferase family 11

    2. NM_001405895.1 → NP_001392824.1  galactoside 2-alpha-L-fucosyltransferase Sec1

      Status: VALIDATED

      Source sequence(s)
      AC167242
      UniProtKB/TrEMBL
      Q8CDC9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45327110..45343825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541010.4 → XP_006541073.1  galactoside 2-alpha-L-fucosyltransferase Sec1 isoform X2

      UniProtKB/TrEMBL
      Q496T8
      Conserved Domains (1) summary
      pfam01531
      Location:4 → 277
      Glyco_transf_11; Glycosyl transferase family 11

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019934.2: Suppressed sequence

      Description
      NM_019934.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97353.1 GenPept UniProtKB/Swiss-Prot:P97353

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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