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    Zfp235 zinc finger protein 235 [ Mus musculus (house mouse) ]

    Gene ID: 56525, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp235provided by MGI
    Official Full Name
    zinc finger protein 235provided by MGI
    Primary source
    MGI:MGI:1929117
    See related
    Ensembl:ENSMUSG00000047603 AllianceGenome:MGI:1929117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610030O19Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in metanephros and testis. Orthologous to human ZNF235 (zinc finger protein 235). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 2.5), cerebellum adult (RPKM 2.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 10.27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23830452..23842669)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24132372..24143244)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18250 Neighboring gene zinc finger protein 180 Neighboring gene zinc finger protein 112 Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene STARR-seq mESC enhancer starr_18251 Neighboring gene zinc finger protein 114 Neighboring gene zinc finger protein 111

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107482

    General protein information

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    Preferred Names
    zinc finger protein 235

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360465.1 → NP_001347394.1  zinc finger protein 235 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC138791, AK147833
      Conserved Domains (4) summary
      COG5048
      Location:355 → 696
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:685 → 768
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:411 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 48
      KRAB; KRAB box

    2. NM_019941.3 → NP_064325.2  zinc finger protein 235 isoform 2

      See identical proteins and their annotated locations for NP_064325.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC138791
      Consensus CDS
      CCDS39825.1
      UniProtKB/TrEMBL
      Q499D5
      Conserved Domains (4) summary
      COG5048
      Location:285 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:615 → 698
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:341 → 361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 48
      KRAB; KRAB box

    RNA

    1. NR_153441.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC138791, AK045726

    2. NR_153442.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC138791, AK139127

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      23830452..23842669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153273.1 → XP_036009166.1  zinc finger protein 235 isoform X2

      UniProtKB/TrEMBL
      Q499D5
      Related
      ENSMUSP00000050803.8, ENSMUST00000056549.9
      Conserved Domains (4) summary
      COG5048
      Location:285 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:615 → 698
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:341 → 361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 48
      KRAB; KRAB box

    2. XM_036153272.1 → XP_036009165.1  zinc finger protein 235 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:316 → 657
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:646 → 729
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:372 → 392
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:39 → 79
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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