Papolb poly (A) polymerase beta (testis specific) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Papolbprovided by MGI
Official Full Name: poly (A) polymerase beta (testis specific)provided by MGI
Primary source: MGI:MGI:1932115
See related: Ensembl:ENSMUSG00000074817 AllianceGenome:MGI:1932115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAP; Papt; Tpap; Paplob; Plap-ps; Papola-ps
Summary: Predicted to enable polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to act upstream of or within RNA polyadenylation. Located in endoplasmic reticulum and nucleus. Is expressed in ductus deferens; epididymis; skin; and testis. Orthologous to human PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.53 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142513495..142515831, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142527740..142530076, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

While PIWIL1 and YBX2 were associated with translationally inactive messenger ribonucleoproteins and translating polyribosomes, PAPOLB was present almost exclusively in the mRNA-free fractions of sucrose gradients. These results suggest that PAPOLB may regulate spermiogenesis through a pathway distinct from that mediated by chromatoid body-associated factors.
Title: PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factors.
expression of GSG1 stimulates TPAP targeting to the ER, suggesting that interactions between the two proteins lead to the redistribution of TPAP from the cytosol to the ER
Title: Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions.
propose that TPAP governs germ cell morphogenesis by modulating specific transcription factors at posttranscriptional and posttranslational levels
Title: Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP.
spermatogenesis requires the cytoplasmic elongation of the mRNA poly(A) tails catalyzed by TPAP
Title: Transgenic expression of testis-specific poly(A) polymerase TPAP in wild-type and TPAP-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Papolb (e-PCR), detects polymorphism
- UniSTS:526975

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: poly(A) polymerase beta

Names: PAP-beta; polynucleotide adenylyltransferase beta; testis-specific poly(A) polymerase

NP_064327.1

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019943.2 → NP_064327.1 poly(A) polymerase beta

See identical proteins and their annotated locations for NP_064327.1

Status: VALIDATED

Source sequence(s)

CAAA01187077

Consensus CDS

CCDS39362.1

UniProtKB/Swiss-Prot

Q9R1R3, Q9WVP6

UniProtKB/TrEMBL

A1L349

Related

ENSMUSP00000100595.2, ENSMUST00000099400.3

Conserved Domains (3) summary

PTZ00418
Location:10 → 569

PTZ00418; Poly(A) polymerase; Provisional

pfam04926
Location:367 → 508

PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain

pfam04928
Location:22 → 364

PAP_central; Poly(A) polymerase central domain