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    Ankrd49 ankyrin repeat domain 49 [ Mus musculus (house mouse) ]

    Gene ID: 56503, updated on 7-Apr-2024

    Summary

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    Official Symbol
    Ankrd49provided by MGI
    Official Full Name
    ankyrin repeat domain 49provided by MGI
    Primary source
    MGI:MGI:1930842
    See related
    Ensembl:ENSMUSG00000031931 AllianceGenome:MGI:1930842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gbif
    Summary
    Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in nucleus. Predicted to be active in cytosol. Orthologous to human ANKRD49 (ankyrin repeat domain 49). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 10.2), liver E14 (RPKM 7.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A2; 9 4.33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14690916..14695869, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14779620..14784573, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23359 Neighboring gene RIKEN cDNA 1700012B09 gene Neighboring gene fucosyltransferase 4 Neighboring gene STARR-seq mESC enhancer starr_23360 Neighboring gene MRE11A homolog A, double strand break repair nuclease Neighboring gene macrophage migration inhibitory factor, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway. Liu YH, et al. J Cell Mol Med, 2022 Aug. PMID 35775112, Free PMC Article
    2. The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway. Wang HL, et al. PLoS One, 2015. PMID 26043108, Free PMC Article
    3. Cloning and characterization of a potential transcriptional activator of human gamma-globin genes. Yang Y, et al. Blood Cells Mol Dis, 2001 Jan-Feb. PMID 11162141
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway.
      Title: ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway.
    2. ANKRD49 plays an important role in spermatogenesis via promotion of autophagy-dependent survival.
      Title: The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25252

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 49
    Names
    fetal globin inducing factor
    fetal globin-increasing factor
    globin inducing factor, fetal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348260.1 → NP_001335189.1  ankyrin repeat domain-containing protein 49

      Status: VALIDATED

      Source sequence(s)
      AK132850, AK137504, BY547905, CD548941, CF105634, CT030247
      Consensus CDS
      CCDS22826.1
      UniProtKB/Swiss-Prot
      Q8VE42, Q9Z2S1
      Related
      ENSMUSP00000149874.2, ENSMUST00000216037.2
      Conserved Domains (2) summary
      sd00045
      Location:77 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:77 → 169
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_019683.4 → NP_062657.2  ankyrin repeat domain-containing protein 49

      See identical proteins and their annotated locations for NP_062657.2

      Status: VALIDATED

      Source sequence(s)
      AK132850, AK137504, BY204553, BY547905, CD548941
      Consensus CDS
      CCDS22826.1
      UniProtKB/Swiss-Prot
      Q8VE42, Q9Z2S1
      Related
      ENSMUSP00000151079.2, ENSMUST00000216372.2
      Conserved Domains (2) summary
      sd00045
      Location:77 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:77 → 169
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      14690916..14695869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510503.3 → XP_006510566.1  ankyrin repeat domain-containing protein 49 isoform X1

      See identical proteins and their annotated locations for XP_006510566.1

      UniProtKB/Swiss-Prot
      Q8VE42, Q9Z2S1
      Conserved Domains (2) summary
      sd00045
      Location:77 → 104
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:77 → 169
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE42.1 GenPept UniProtKB/Swiss-Prot:Q8VE42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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