Naa80 N(alpha)-acetyltransferase 80, NatH catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naa80provided by MGI
Official Full Name: N(alpha)-acetyltransferase 80, NatH catalytic subunitprovided by MGI
Primary source: MGI:MGI:1888902
See related: Ensembl:ENSMUSG00000079334 AllianceGenome:MGI:1888902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fus2; Nat6
Summary: Predicted to enable acetyl-CoA binding activity and peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation; actin modification; and regulation of actin polymerization or depolymerization. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in heart ventricle; liver; and metanephros. Orthologous to human NAA80 (N-alpha-acetyltransferase 80, NatH catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 51.4), liver adult (RPKM 33.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 58.18 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107457868..107461247)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107580669..107584048)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
Title: The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.
Title: Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.

Submit: New GeneRIF Correction

General gene information

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Markers

RH136004 (e-PCR)
- UniSTS:210000

AF011567 (e-PCR)
- UniSTS:163468

Hyal1 (e-PCR), detects polymorphism
- UniSTS:526011

Nat6 (e-PCR), detects polymorphism
- UniSTS:526016

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-aspartic acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-glutamic acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in actin modification	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 80

Names: N-acetyltransferase 6; protein fus-2; protein fusion-2 homolog

NP_062724.1

EC 2.3.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019750.4 → NP_062724.1 N-alpha-acetyltransferase 80

See identical proteins and their annotated locations for NP_062724.1

Status: VALIDATED

Source sequence(s)

AK137391, BY203919

Consensus CDS

CCDS23498.1

UniProtKB/Swiss-Prot

Q8QZY5, Q8R014, Q9ERM0, Q9R123

UniProtKB/TrEMBL

Q3UVC9

Related

ENSMUSP00000091300.5, ENSMUST00000093785.6

Conserved Domains (1) summary

cd04301
Location:148 → 203

NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate