Pfkp phosphofructokinase, platelet [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pfkpprovided by MGI
Official Full Name: phosphofructokinase, plateletprovided by MGI
Primary source: MGI:MGI:1891833
See related: Ensembl:ENSMUSG00000021196 AllianceGenome:MGI:1891833
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PFK-C; PFK-P; ATP-PFK; 1200015H23Rik; 9330125N24Rik
Summary: Predicted to enable several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and urinary system. Orthologous to human PFKP (phosphofructokinase, platelet). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 90.3), CNS E14 (RPKM 34.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 3.25 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (6629910..6699096, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (6579874..6649060, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.
Title: Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.
SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure.
Title: SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure.
PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease.
Title: PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18950 (e-PCR)
- UniSTS:124785

27.MMHAP32FLA6.seq (e-PCR)
- UniSTS:123781

RH124918 (e-PCR)
- UniSTS:161740

Pfkp (e-PCR), detects polymorphism
- UniSTS:507132

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 6-phosphofructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphofructokinase activity	ISO Inferred from Sequence Orthology more info
enables 6-phosphofructokinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fructose-6-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-6-phosphate binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolytic process through fructose-6-phosphate	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 6-phosphofructokinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of 6-phosphofructokinase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent 6-phosphofructokinase, platelet type

Names: 6-phosphofructokinase type C; ATP:D-fructose 6-phosphate 1-phosphotransferase; phosphofructo-1-kinase isozyme C; phosphofructokinase 1; phosphohexokinase

NP_001278000.1

EC 2.7.1.11

NP_062677.1

EC 2.7.1.11

XP_006516550.1

EC 2.7.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291071.1 → NP_001278000.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 2

See identical proteins and their annotated locations for NP_001278000.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and contains an alternate in-frame exon, both in the 3' coding region, compared to variant 1. This results in isoform 2, which is of the same size, but includes a different internal in-frame segment, compared to isoform 1.

Source sequence(s)

AK049841, AK076803, BY243493

Consensus CDS

CCDS70427.1

UniProtKB/TrEMBL

Q8C605

Related

ENSMUSP00000021614.8, ENSMUST00000021614.14

Conserved Domains (2) summary

cd00764
Location:21 → 779

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

TIGR02478
Location:24 → 763

6PF1K_euk; 6-phosphofructokinase, eukaryotic type
NM_019703.4 → NP_062677.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 1

See identical proteins and their annotated locations for NP_062677.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AK049841, BY243493

Consensus CDS

CCDS26230.1

UniProtKB/Swiss-Prot

Q3TNA9, Q3U4P1, Q3U7G4, Q4KUG1, Q543K8, Q8C5I6, Q9JI86, Q9WUA3

Related

ENSMUSP00000117030.2, ENSMUST00000138703.8

Conserved Domains (2) summary

cd00764
Location:21 → 779

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

TIGR02478
Location:24 → 763

6PF1K_euk; 6-phosphofructokinase, eukaryotic type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

6629910..6699096 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516487.5 → XP_006516550.1 ATP-dependent 6-phosphofructokinase, platelet type isoform X1

Conserved Domains (1) summary

cl00204
Location:21 → 728

PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. ...