Adar adenosine deaminase, RNA-specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adarprovided by MGI
Official Full Name: adenosine deaminase, RNA-specificprovided by MGI
Primary source: MGI:MGI:1889575
See related: Ensembl:ENSMUSG00000027951 AllianceGenome:MGI:1889575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adar1; DRADA; mZaADAR; Adar1p110; Adar1p150
Summary: Enables double-stranded RNA adenosine deaminase activity. Involved in several processes, including adenosine to inosine editing; negative regulation of protein kinase activity by regulation of protein phosphorylation; and positive regulation of viral genome replication. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; immune system development; and regulation of gene expression. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 21.4), cerebellum adult (RPKM 21.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.19 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89622321..89660756)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89714469..89753455)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAR1 regulates macrophage polarization and is protective against liver ischemia and reperfusion injury.
Title: ADAR1 regulates macrophage polarization and is protective against liver ischemia and reperfusion injury.
ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling.
Title: ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling.
Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment.
Title: Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment.
ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.
Title: ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.
ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis.
Title: ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis.
Generation of a new Adar1p150 [-/-] mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis.
Title: Generation of a new Adar1p150 (-/-) mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis.
ADAR1 Zalpha domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.
Title: ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.
RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.
Title: RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.
An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa.
Title: An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa.
The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms.
Title: The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms.

Submit: New GeneRIF Correction See all GeneRIFs (99)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (13) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (18) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adar (e-PCR), detects polymorphism
- UniSTS:506711

UniSTS:479064 (e-PCR)
- UniSTS:479064

Adar (e-PCR), detects polymorphism
- UniSTS:479064

AW822028 (e-PCR)
- UniSTS:207526

AV242451 (e-PCR)
- UniSTS:178866

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA adenosine deaminase activity	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables left-handed Z-DNA binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tRNA-specific adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RISC complex assembly	ISO Inferred from Sequence Orthology more info	PubMed
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine to inosine editing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenosine to inosine editing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenosine to inosine editing	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within base conversion or substitution editing	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing by regulatory ncRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic diversification of immune receptors via somatic mutation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of supraspliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: double-stranded RNA-specific adenosine deaminase

Names: RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form

NP_001033676.2

EC 3.5.4.37

NP_001139768.1

EC 3.5.4.37

NP_001344887.1

EC 3.5.4.37

NP_001397587.1

EC 3.5.4.37

NP_001397588.1

EC 3.5.4.37

NP_001397589.1

EC 3.5.4.37

NP_001397590.1

EC 3.5.4.37

NP_001397591.1

EC 3.5.4.37

NP_001397592.1

EC 3.5.4.37

NP_001397593.1

EC 3.5.4.37

NP_062629.3

EC 3.5.4.37

XP_006501816.3

EC 3.5.4.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038587.5 → NP_001033676.2 double-stranded RNA-specific adenosine deaminase isoform 2

See identical proteins and their annotated locations for NP_001033676.2

Status: VALIDATED

Source sequence(s)

AC102392, AC166364

Consensus CDS

CCDS17514.1

UniProtKB/TrEMBL

Q3UH31

Related

ENSMUSP00000096525.3, ENSMUST00000098924.9

Conserved Domains (5) summary

smart00552
Location:540 → 923

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cl02659
Location:1 → 64

z-alpha; Adenosine deaminase z-alpha domain

cd19913
Location:207 → 277

DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)

cd19915
Location:426 → 496

DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins

cl00054
Location:318 → 388

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_001146296.2 → NP_001139768.1 double-stranded RNA-specific adenosine deaminase isoform 3

See identical proteins and their annotated locations for NP_001139768.1

Status: VALIDATED

Source sequence(s)

AC102392, AC166364

Consensus CDS

CCDS50963.1

UniProtKB/Swiss-Prot

O70375, Q80UZ6, Q8C222, Q99MU2, Q99MU3, Q99MU4, Q99MU7

UniProtKB/TrEMBL

Q4FJS9

Related

ENSMUSP00000103028.3, ENSMUST00000107405.6

Conserved Domains (4) summary

smart00358
Location:457 → 522

DSRM; Double-stranded RNA binding motif

smart00552
Location:788 → 1171

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:137 → 203

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:248 → 312

z-alpha; Adenosine deaminase z-alpha domain
NM_001357958.2 → NP_001344887.1 double-stranded RNA-specific adenosine deaminase isoform 4

Status: VALIDATED

Source sequence(s)

AC102392, AC166364

UniProtKB/TrEMBL

Q4FJS9

Conserved Domains (4) summary

smart00358
Location:496 → 561

DSRM; Double-stranded RNA binding motif

smart00552
Location:827 → 1210

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:176 → 242

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:287 → 351

z-alpha; Adenosine deaminase z-alpha domain
NM_001410658.1 → NP_001397587.1 double-stranded RNA-specific adenosine deaminase isoform 5

Status: VALIDATED

Source sequence(s)

AC102392, AC166364
NM_001410659.1 → NP_001397588.1 double-stranded RNA-specific adenosine deaminase isoform 2

Status: VALIDATED

Source sequence(s)

AC102392, AC166364
NM_001410660.1 → NP_001397589.1 double-stranded RNA-specific adenosine deaminase isoform 6

Status: VALIDATED

Source sequence(s)

AC102392, AC166364
NM_001410661.1 → NP_001397590.1 double-stranded RNA-specific adenosine deaminase isoform 7

Status: VALIDATED

Source sequence(s)

AC102392, AC166364
NM_001410662.1 → NP_001397591.1 double-stranded RNA-specific adenosine deaminase isoform 8

Status: VALIDATED

Source sequence(s)

AC102392, AC166364

Related

ENSMUSP00000113453.2, ENSMUST00000118341.6
NM_001410663.1 → NP_001397592.1 double-stranded RNA-specific adenosine deaminase isoform 9

Status: VALIDATED

Source sequence(s)

AC102392, AC166364
NM_001410664.1 → NP_001397593.1 double-stranded RNA-specific adenosine deaminase isoform 9

Status: VALIDATED

Source sequence(s)

AC102392, AC166364

Related

ENSMUSP00000112969.2, ENSMUST00000121094.8
NM_019655.4 → NP_062629.3 double-stranded RNA-specific adenosine deaminase isoform 1

See identical proteins and their annotated locations for NP_062629.3

Status: VALIDATED

Source sequence(s)

AC102392, AC166364

Consensus CDS

CCDS17513.1

UniProtKB/TrEMBL

Q4FJS9

Related

ENSMUSP00000029563.9, ENSMUST00000029563.14

Conserved Domains (4) summary

smart00358
Location:457 → 522

DSRM; Double-stranded RNA binding motif

smart00552
Location:762 → 1145

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:137 → 203

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:248 → 312

z-alpha; Adenosine deaminase z-alpha domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

89622321..89660756

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501753.5 → XP_006501816.3 double-stranded RNA-specific adenosine deaminase isoform X1

UniProtKB/TrEMBL

Q4FJS9

Conserved Domains (6) summary

smart00552
Location:816 → 1199

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:191 → 257

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:302 → 366

z-alpha; Adenosine deaminase z-alpha domain

cd19913
Location:509 → 579

DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)

cd19915
Location:728 → 798

DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins

cl00054
Location:620 → 690

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily