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    Dusp14 dual specificity phosphatase 14 [ Mus musculus (house mouse) ]

    Gene ID: 56405, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dusp14provided by MGI
    Official Full Name
    dual specificity phosphatase 14provided by MGI
    Primary source
    MGI:MGI:1927168
    See related
    Ensembl:ENSMUSG00000018648 AllianceGenome:MGI:1927168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mkp6; MKP-L; D11Ertd395e; 1110014C10Rik; 2310042C07Rik
    Summary
    Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human DUSP14 (dual specificity phosphatase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 19.6), frontal lobe adult (RPKM 14.7) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 C; 11 51.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83938859..83960016, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84048033..84069256, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5256 Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene DExD box helicase 52 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene transcriptional adaptor 2A Neighboring gene acetyl-Coenzyme A carboxylase alpha Neighboring gene predicted gene 11437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DUSP14 knockout accelerates cardiac ischemia reperfusion (IR) injury through activating NF-κB and MAPKs signaling pathways modulated by ROS generation. Lin B, et al. Biochem Biophys Res Commun, 2018 Jun 18. PMID 29660332
    2. Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKα-dependent manner. Hong L, et al. Biochem Biophys Res Commun, 2019 Nov 12. PMID 31526569
    3. DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by reducing inflammation and apoptosis via the activation of Nrf-2. Jianrong S, et al. Biochem Biophys Res Commun, 2019 Feb 12. PMID 30638656
    4. Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver. Wang S, et al. Hepatology, 2018 Apr. PMID 29077210
    5. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. Yang CY, et al. J Immunol, 2014 Feb 15. PMID 24403530

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that dual specificity phosphatase 14 (Dusp14) as an important molecular switch resulting in osteoporosis through an protein kinase AMP-activated alpha 1 catalytic subunit (AMPKalpha)-dependent manner.
      Title: Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKα-dependent manner.
    2. DUSP14 up-regulation inhibits inflammation and oxidative stress in brain of cerebral ischemia/reperfusion mice. DUSP14 evokes Nrf-2-meditated anti-oxidative stress and inflammatory response.
      Title: DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by reducing inflammation and apoptosis via the activation of Nrf-2.
    3. Hepatocyte DUSP14 is required for maintaining hepatic metabolic homeostasis and for suppressing inflammation, a novel function that relies on constraining TAK1 hyperactivation
      Title: Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver.
    4. DUSP14-knockdown in primary cardiomyocytes using its specific siRNA sequence elevated hypoxia and reoxygenation-induced activation of NF-kappaB and MAPKs signaling pathways, and reactive oxygen species generation.
      Title: DUSP14 knockout accelerates cardiac ischemia reperfusion (IR) injury through activating NF-κB and MAPKs signaling pathways modulated by ROS generation.
    5. protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction possibly through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway
      Title: Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.
    6. DUSP14 negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation.
      Title: Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
    7. dual specificity phosphatases (Dusps) 6 and 14 are up-regulated by activation of beta-catenin in murine liver cells
      Title: Dual-specificity phosphatases are targets of the Wnt/β-catenin pathway and candidate mediators of β-catenin/Ras signaling interactions.
    8. knockdown of CREMalpha or DUSP14 or expression of a dominant-negative form of DUSP14 increased beta-cell line proliferation and enhanced the GLP-1-induced proliferation of primary beta-cells
      Title: Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.
    9. critical role for JNK1 in the regulation of Mkp1 induction and in LPS-dependent macrophage activation.
      Title: JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 14
    Names
    MAP kinase phosphatase 6
    MAP kinase phsophatase 6
    Mkp-1 like protein tyrosine phosphatase
    mitogen-activated protein kinase phosphatase 6
    NP_001395670.1
    NP_001395671.1
    NP_001395672.1
    NP_001395673.1
    NP_001395674.1
    NP_001395675.1
    NP_062793.2
    XP_036012759.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408741.1 → NP_001395670.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Related
      ENSMUSP00000103736.2, ENSMUST00000108101.8

    2. NM_001408742.1 → NP_001395671.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4

    3. NM_001408743.1 → NP_001395672.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Related
      ENSMUSP00000130624.2, ENSMUST00000164891.8

    4. NM_001408744.1 → NP_001395673.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4
      Related
      ENSMUSP00000018792.6, ENSMUST00000018792.12

    5. NM_001408745.1 → NP_001395674.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4

    6. NM_001408746.1 → NP_001395675.1  dual specificity protein phosphatase 14

      Status: VALIDATED

      Source sequence(s)
      AL645615
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4

    7. NM_019819.4 → NP_062793.2  dual specificity protein phosphatase 14

      See identical proteins and their annotated locations for NP_062793.2

      Status: VALIDATED

      Source sequence(s)
      AL645615
      Consensus CDS
      CCDS25182.1
      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
      Related
      ENSMUSP00000098271.5, ENSMUST00000100705.11
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83938859..83960016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156866.1 → XP_036012759.1  dual specificity protein phosphatase 14 isoform X1

      UniProtKB/Swiss-Prot
      Q9D715, Q9JLY7
      UniProtKB/TrEMBL
      Q542U4, Q7TPY1
      Conserved Domains (1) summary
      cd14572
      Location:20 → 169
      DUSP14; dual specificity protein phosphatase 14
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLY7.2 GenPept UniProtKB/Swiss-Prot:Q9JLY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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