Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naa10provided by MGI
Official Full Name: N(alpha)-acetyltransferase 10, NatA catalytic subunitprovided by MGI
Primary source: MGI:MGI:1915255
See related: Ensembl:ENSMUSG00000031388 AllianceGenome:MGI:1915255
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Te2; Ard1; Ard1a; 2310039H09Rik
Summary: Enables N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-glutamic acid acetylation; N-terminal peptidyl-serine acetylation; and negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric. Located in cytoplasm. Is expressed in submandibular gland primordium and testis. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 30.5), large intestine adult (RPKM 29.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.49 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72960476..72965550, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73916870..73921944, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway.
Title: Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway.
Naa10p-mediated N-terminal acetylation of Pgc1alpha downregulates thermogenic gene expression in beige adipocytes.
Title: Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α.
we established Naa10 knockout mESCs to test this hypothesis. We found that Naa10 deficiency attenuated differentiation towards the epiblast lineage, deviating towards primitive endoderm.
Title: The N-end rule pathway enzyme Naa10 supports epiblast specification in mouse embryonic stem cells by modulating FGF/MAPK.
Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.
Title: Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10).
The lethal Ogden syndrome-associated mutation of Naa10p disrupts its binding to the imprinting control region of H19 and Dnmt1 recruitment.
Title: The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.
NAA10 acts as a guard ensuring balanced osteogenesis by fine-tuning Runx2 signalling in a feedback manner.
Title: NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2.
ARD1 has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA.
Title: Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A.
mARD1A(225) may be a novel upstream target that blocks VEGFA expression and tumor-related angiogenesis.
Title: Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis.
Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.
Title: An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development.
Mouse ortholog (225) of ARD1 strongly decreased the level of hypoxia inducible factor (HIF)-1 alpha and increased the extent of acetylation, whereas mARD1(235) variants had a much weaker effect on HIF-1 alpha stability and acetylation.
Title: Characterization of ARD1 variants in mammalian cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN88217 (e-PCR)
- UniSTS:413015

REN88218 (e-PCR)
- UniSTS:413016

Naa10 (e-PCR), detects polymorphism
- UniSTS:528303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
contributes_to peptide alpha-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide alpha-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide-glutamate-alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-serine-alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ribosome binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NatA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatA complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 10

Names: ARD1 homolog A, N-acetyltransferase; N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10; N-terminal acetyltransferase complex ARD1 subunit homolog A; Nalpha acetyltransferase 10; alpha-N-acetyltransferase 1A; natA catalytic subunit Naa10

NP_001171436.1

EC 2.3.1.255

NP_001297467.1

EC 2.3.1.255

NP_063923.1

EC 2.3.1.255

XP_036017930.1

EC 2.3.1.255

XP_036017931.1

EC 2.3.1.255

XP_036017932.1

EC 2.3.1.255

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177965.1 → NP_001171436.1 N-alpha-acetyltransferase 10 isoform 2

See identical proteins and their annotated locations for NP_001171436.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK003806, AL672002, BY101790

Consensus CDS

CCDS53102.1

UniProtKB/TrEMBL

Q3V4D5, Q8R2U5

Related

ENSMUSP00000110031.4, ENSMUST00000114389.10

Conserved Domains (2) summary

COG0456
Location:1 → 149

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:47 → 122

Acetyltransf_1; Acetyltransferase (GNAT) family
NM_001310538.1 → NP_001297467.1 N-alpha-acetyltransferase 10 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK003806, BY101790, CN666135

Consensus CDS

CCDS81139.1

UniProtKB/TrEMBL

B1AUY9

Related

ENSMUSP00000110029.2, ENSMUST00000114387.8

Conserved Domains (1) summary

COG0456
Location:1 → 149

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
NM_019870.3 → NP_063923.1 N-alpha-acetyltransferase 10 isoform 1

See identical proteins and their annotated locations for NP_063923.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript but encodes the longest isoform (1).

Source sequence(s)

AL672002

Consensus CDS

CCDS30217.1

UniProtKB/Swiss-Prot

Q9QY36

UniProtKB/TrEMBL

B1AUY7, Q540H0

Related

ENSMUSP00000033763.9, ENSMUST00000033763.15

Conserved Domains (1) summary

COG0456
Location:1 → 149

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

72960476..72965550 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162037.1 → XP_036017930.1 N-alpha-acetyltransferase 10 isoform X1

UniProtKB/TrEMBL

Q684Q8

Conserved Domains (1) summary

COG0456
Location:15 → 138

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
XM_036162039.1 → XP_036017932.1 N-alpha-acetyltransferase 10 isoform X3

Conserved Domains (1) summary

COG0456
Location:15 → 138

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
XM_036162038.1 → XP_036017931.1 N-alpha-acetyltransferase 10 isoform X2

UniProtKB/TrEMBL

Q8R2U5

Conserved Domains (1) summary

COG0456
Location:15 → 138

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]