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    Hdac7 histone deacetylase 7 [ Mus musculus (house mouse) ]

    Gene ID: 56233, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hdac7provided by MGI
    Official Full Name
    histone deacetylase 7provided by MGI
    Primary source
    MGI:MGI:1891835
    See related
    Ensembl:ENSMUSG00000022475 AllianceGenome:MGI:1891835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik
    Summary
    Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within cell-cell junction assembly; negative regulation of transcription by RNA polymerase II; and vasculogenesis. Predicted to be located in cytosol and nucleus. Predicted to be part of histone deacetylase complex. Is expressed in adrenal gland; embryo; eye; inner ear; and otocyst. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 141.4), lung adult (RPKM 54.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hdac7 in Genome Data Viewer
    Location:
    15 F1; 15 53.79 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97690542..97742383, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97792661..97844502, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene STARR-seq mESC enhancer starr_39638 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E5513 Neighboring gene predicted gene, 46535 Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E10877 Neighboring gene STARR-positive B cell enhancer ABC_E1916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97659351-97659504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97666932-97667248 Neighboring gene predicted gene, 33636 Neighboring gene predicted gene, 33690 Neighboring gene STARR-seq mESC enhancer starr_39643 Neighboring gene vitamin D (1,25-dihydroxyvitamin D3) receptor Neighboring gene predicted gene, 52171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Axisa PP, et al. Sci Transl Med, 2022 Dec 14. PMID 36516268
    2. HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. Ye J, et al. Mol Neurobiol, 2022 Oct. PMID 35871708, Free PMC Article
    3. A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation. Yang J, et al. Stem Cells, 2020 Apr. PMID 31721359, Free PMC Article
    4. HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation. Jing X, et al. J Neurosci, 2017 Apr 5. PMID 28283560, Free PMC Article
    5. Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance. Kasler HG, et al. EMBO J, 2012 Nov 28. PMID 23103766, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.
      Title: SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.
    2. Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
      Title: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
    3. A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.
      Title: A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.
    4. HDAC7 Activates IKK/NF-kappaB Signaling to Regulate Astrocyte-Mediated Inflammation.
      Title: HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation.
    5. Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
      Title: Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
    6. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
      Title: Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
    7. HDAC7 is a bona fide transcriptional repressor essential for B cell development.
      Title: In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.
    8. In the dorsal hippocampus, HDAC7 expression is decreased following contextual fear conditioning.
      Title: HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation.
    9. This study demonstrated that hdac7 decrease in skeletal muscle in muscle atrophy.
      Title: Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
    10. HDAC7 in osteoclasts is an important molecular regulator of MITF activity and bone homeostasis.
      Title: Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein lysine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in B cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of striated muscle tissue development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone deacetylase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone deacetylase 7
    Names
    histone deacetylase 7A
    NP_001191204.1
    NP_001191205.1
    NP_001191206.1
    NP_001191207.1
    NP_001191208.1
    NP_001191209.1
    NP_001191210.1
    NP_001365900.1
    NP_062518.2
    XP_006521268.1
    XP_006521270.1
    XP_006521271.1
    XP_006521272.1
    XP_006521273.1
    XP_030104529.1
    XP_036015418.1
    XP_036015419.1
    XP_036015420.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204275.1 → NP_001191204.1  histone deacetylase 7 isoform 1

      See identical proteins and their annotated locations for NP_001191204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57006.1
      UniProtKB/TrEMBL
      Q6KAT4
      Related
      ENSMUSP00000112110.3, ENSMUST00000116409.9
      Conserved Domains (2) summary
      cd10008
      Location:522 → 897
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:100 → 503
      PHA03247; large tegument protein UL36; Provisional

    2. NM_001204276.1 → NP_001191205.1  histone deacetylase 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57005.1
      UniProtKB/TrEMBL
      Q6KAT4
      Related
      ENSMUSP00000113380.2, ENSMUST00000118294.8
      Conserved Domains (1) summary
      cd10008
      Location:515 → 890
      HDAC7; Histone deacetylase 7

    3. NM_001204277.1 → NP_001191206.1  histone deacetylase 7 isoform 3

      See identical proteins and their annotated locations for NP_001191206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK044287, BB648696
      Consensus CDS
      CCDS57007.1
      UniProtKB/TrEMBL
      Q6KAT4
      Related
      ENSMUSP00000078766.8, ENSMUST00000079838.14
      Conserved Domains (1) summary
      cd10008
      Location:513 → 888
      HDAC7; Histone deacetylase 7

    4. NM_001204278.1 → NP_001191207.1  histone deacetylase 7 isoform 5

      See identical proteins and their annotated locations for NP_001191207.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57004.1
      UniProtKB/TrEMBL
      Q6KAT4
      Related
      ENSMUSP00000112109.3, ENSMUST00000116408.9
      Conserved Domains (1) summary
      cd10008
      Location:485 → 860
      HDAC7; Histone deacetylase 7

    5. NM_001204279.1 → NP_001191208.1  histone deacetylase 7 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57001.1
      UniProtKB/TrEMBL
      E9PXW1, Q6KAT4
      Related
      ENSMUSP00000112459.2, ENSMUST00000119670.8
      Conserved Domains (1) summary
      cd10008
      Location:461 → 836
      HDAC7; Histone deacetylase 7

    6. NM_001204280.1 → NP_001191209.1  histone deacetylase 7 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57003.1
      UniProtKB/TrEMBL
      E9PXW8, Q6KAT4
      Related
      ENSMUSP00000112446.2, ENSMUST00000120683.8
      Conserved Domains (1) summary
      cl17011
      Location:485 → 812
      Arginase_HDAC; Arginase-like and histone-like hydrolases

    7. NM_001204281.1 → NP_001191210.1  histone deacetylase 7 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
      Source sequence(s)
      AC158787
      Consensus CDS
      CCDS57002.1
      UniProtKB/TrEMBL
      E9PX62, Q6KAT4
      Related
      ENSMUSP00000112641.2, ENSMUST00000121514.8
      Conserved Domains (1) summary
      cd10008
      Location:420 → 795
      HDAC7; Histone deacetylase 7

    8. NM_001378971.1 → NP_001365900.1  histone deacetylase 7 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC158787
      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:544 → 919
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:122 → 525
      PHA03247; large tegument protein UL36; Provisional

    9. NM_019572.3 → NP_062518.2  histone deacetylase 7 isoform 4

      See identical proteins and their annotated locations for NP_062518.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK044287, BB648696, BC057332
      Consensus CDS
      CCDS37188.1
      UniProtKB/Swiss-Prot
      Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72
      UniProtKB/TrEMBL
      Q6KAT4
      Related
      ENSMUSP00000085744.6, ENSMUST00000088402.12
      Conserved Domains (1) summary
      cd10008
      Location:507 → 882
      HDAC7; Histone deacetylase 7

    RNA

    1. NR_166212.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158787

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97690542..97742383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159526.1 → XP_036015419.1  histone deacetylase 7 isoform X4

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:500 → 875
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:122 → 499
      PHA03247; large tegument protein UL36; Provisional

    2. XM_030248669.2 → XP_030104529.1  histone deacetylase 7 isoform X3

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:511 → 886
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:20 → 492
      PHA03247; large tegument protein UL36; Provisional

    3. XM_006521210.4 → XP_006521273.1  histone deacetylase 7 isoform X2

      See identical proteins and their annotated locations for XP_006521273.1

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:522 → 897
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:100 → 503
      PHA03247; large tegument protein UL36; Provisional

    4. XM_036159527.1 → XP_036015420.1  histone deacetylase 7 isoform X5

      UniProtKB/TrEMBL
      Q3UJT5
      Conserved Domains (1) summary
      cd10008
      Location:96 → 471
      HDAC7; Histone deacetylase 7

    5. XM_006521208.5 → XP_006521271.1  histone deacetylase 7 isoform X2

      See identical proteins and their annotated locations for XP_006521271.1

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:522 → 897
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:100 → 503
      PHA03247; large tegument protein UL36; Provisional

    6. XM_006521205.3 → XP_006521268.1  histone deacetylase 7 isoform X2

      See identical proteins and their annotated locations for XP_006521268.1

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:522 → 897
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:100 → 503
      PHA03247; large tegument protein UL36; Provisional

    7. XM_006521209.3 → XP_006521272.1  histone deacetylase 7 isoform X2

      See identical proteins and their annotated locations for XP_006521272.1

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:522 → 897
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:100 → 503
      PHA03247; large tegument protein UL36; Provisional

    8. XM_006521207.5 → XP_006521270.1  histone deacetylase 7 isoform X2

      See identical proteins and their annotated locations for XP_006521270.1

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:522 → 897
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:100 → 503
      PHA03247; large tegument protein UL36; Provisional

    9. XM_036159525.1 → XP_036015418.1  histone deacetylase 7 isoform X1

      UniProtKB/TrEMBL
      Q6KAT4
      Conserved Domains (2) summary
      cd10008
      Location:546 → 921
      HDAC7; Histone deacetylase 7
      PHA03247
      Location:124 → 527
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_003951412.1 RNA Sequence

    2. XR_003951415.1 RNA Sequence

    3. XR_003951414.1 RNA Sequence

    4. XR_003951413.1 RNA Sequence

      Related
      ENSMUST00000228466.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C2B3.2 GenPept UniProtKB/Swiss-Prot:Q8C2B3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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