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    Uchl5 ubiquitin carboxyl-terminal esterase L5 [ Mus musculus (house mouse) ]

    Gene ID: 56207, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Uchl5provided by MGI
    Official Full Name
    ubiquitin carboxyl-terminal esterase L5provided by MGI
    Primary source
    MGI:MGI:1914848
    See related
    Ensembl:ENSMUSG00000018189 AllianceGenome:MGI:1914848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Uch37; 5830413B11Rik
    Summary
    Predicted to enable endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in forebrain morphogenesis; lateral ventricle development; and midbrain development. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of Ino80 complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; nose; and orbito-sphenoid. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 10.8), placenta adult (RPKM 8.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 F; 1 62.54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143652993..143683204)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143777234..143807466)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46161 Neighboring gene glutaredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene Ro60, Y RNA binding protein Neighboring gene predicted gene, 25663 Neighboring gene STARR-positive B cell enhancer ABC_E499 Neighboring gene STARR-seq mESC enhancer starr_02532 Neighboring gene STARR-positive B cell enhancer ABC_E5813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:145766106-145766315 Neighboring gene predicted gene, 41964 Neighboring gene STARR-seq mESC enhancer starr_02533 Neighboring gene STARR-positive B cell enhancer ABC_E628 Neighboring gene regulator of G-protein signaling 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs. Zhao W, et al. Int J Biol Sci, 2023. PMID 36778113, Free PMC Article
    2. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells. Ko YM, et al. Arch Biochem Biophys, 2013 Jul 15. PMID 23500140
    3. METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome. Yang X, et al. Exp Cell Res, 2023 Jun 15. PMID 37044315
    4. Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency. Ma YS, et al. Signal Transduct Target Ther, 2020 Apr 1. PMID 32296042, Free PMC Article
    5. Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs. Peth A, et al. J Biol Chem, 2013 Mar 15. PMID 23341450, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.
      Title: METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.
    2. NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
      Title: NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
    3. Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
      Title: Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
    4. PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 protein deubiquitination, p21(WAF1) and fibronectin protein expression and cell hypertrophy.
      Title: Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells.
    5. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction
      Title: Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs.
    6. this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
      Title: Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2)  1 citation
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L5
    Names
    UCH-L5
    ubiquitin C-terminal hydrolase 37
    ubiquitin C-terminal hydrolase UCH37
    ubiquitin thioesterase L5
    NP_001153338.1
    NP_062508.2
    XP_006529823.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159866.1 → NP_001153338.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

      See identical proteins and their annotated locations for NP_001153338.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AK017925, BY279731
      Consensus CDS
      CCDS78699.1
      UniProtKB/Swiss-Prot
      Q9WUP7
      Related
      ENSMUSP00000018333.8, ENSMUST00000018333.13
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:263 → 308
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    2. NM_019562.2 → NP_062508.2  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

      See identical proteins and their annotated locations for NP_062508.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF148447, AL592403, BY279731
      Consensus CDS
      CCDS15346.1
      UniProtKB/Swiss-Prot
      Q9CVJ4, Q9CXZ3, Q9R107, Q9WUP7
      Related
      ENSMUSP00000140106.2, ENSMUST00000189936.7
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:264 → 309
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      143652993..143683204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529760.5 → XP_006529823.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:264 → 309
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    RNA

    1. XR_387185.5 RNA Sequence

    2. XR_001785184.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUP7.2 GenPept UniProtKB/Swiss-Prot:Q9WUP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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