Pgam2 phosphoglycerate mutase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgam2provided by MGI
Official Full Name: phosphoglycerate mutase 2provided by MGI
Primary source: MGI:MGI:1933118
See related: Ensembl:ENSMUSG00000020475 AllianceGenome:MGI:1933118
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables phosphoglycerate mutase activity. Acts upstream of or within Notch signaling pathway and glycolytic process. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM2 (phosphoglycerate mutase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 618.6), heart adult (RPKM 314.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 3.87 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (5751637..5753796, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (5801637..5803796, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.
Title: Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.
Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice.
Title: Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pgam2 (e-PCR), detects polymorphism
- UniSTS:225870

Pgam2 (e-PCR), detects polymorphism
- UniSTS:547463

Pgam2 (e-PCR), detects polymorphism
- UniSTS:507135

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables bisphosphoglycerate mutase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intramolecular phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycerate mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical glycolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in striated muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphoglycerate mutase 2

Names: BPG-dependent PGAM 2; PGAM-M; muscle-specific phosphoglycerate mutase; phosphoglycerate mutase isozyme M; phosphoglycerate mutase muscle-specific subunit

NP_061358.1

EC 5.4.2.11

EC 5.4.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.