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    Nop58 NOP58 ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 55989, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nop58provided by MGI
    Official Full Name
    NOP58 ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:1933184
    See related
    Ensembl:ENSMUSG00000026020 AllianceGenome:MGI:1933184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIK; MSSP; Nol5; nop5
    Summary
    Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and snoRNA binding activity. Predicted to be involved in snoRNA localization. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in Cajal body; cytosol; and fibrillar center. Predicted to be part of box C/D RNP complex; pre-snoRNP complex; and small-subunit processome. Is expressed in brain; embryo; eye; heart; and pancreas epithelium. Orthologous to human NOP58 (NOP58 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 41.5), liver E14 (RPKM 35.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C2; 1 30.38 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59724165..59751352)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59684961..59711510)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 973 Neighboring gene predicted gene, 33833 Neighboring gene STARR-seq mESC enhancer starr_01052 Neighboring gene STARR-positive B cell enhancer ABC_E9465 Neighboring gene small ubiquitin-like modifier 1 Neighboring gene STARR-positive B cell enhancer ABC_E2544 Neighboring gene STARR-seq mESC enhancer starr_01053 Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene predicted gene, 26293 Neighboring gene STARR-seq mESC enhancer starr_01054 Neighboring gene predicted gene, 26287 Neighboring gene small nucleolar RNA, C/D box 11 Neighboring gene RIKEN cDNA B430105G09 gene Neighboring gene bone morphogenetic protein receptor type 2 Neighboring gene STARR-seq mESC enhancer starr_01055

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleolar Sik-similar protein (Sik-SP) is required for the maintenance of uterine estrogen signaling mechanism via ERα. Chung D, et al. Mol Endocrinol, 2012 Mar. PMID 22282469, Free PMC Article
    2. Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Yang Y, et al. Mol Biol Cell, 2000 Feb. PMID 10679015, Free PMC Article
    3. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. Marie-Cardine A, et al. J Exp Med, 1999 Apr 19. PMID 10209036, Free PMC Article
    4. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Wang X, et al. Mol Cell, 2020 Mar 5. PMID 32017896
    5. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TFIID-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snoRNA localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pre-snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 58
    Names
    NOP58 ribonucleoprotein homolog
    SIK similar protein
    nucleolar protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420730.1 → NP_001407659.1  nucleolar protein 58 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC147254

    2. NM_001420731.1 → NP_001407660.1  nucleolar protein 58 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC147254

    3. NM_001420732.1 → NP_001407661.1  nucleolar protein 58 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC147254

    4. NM_001420733.1 → NP_001407662.1  nucleolar protein 58 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147254

    5. NM_001420734.1 → NP_001407663.1  nucleolar protein 58 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147254

    6. NM_001420735.1 → NP_001407664.1  nucleolar protein 58 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147254

    7. NM_001420736.1 → NP_001407665.1  nucleolar protein 58 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147254

    8. NM_001420737.1 → NP_001407666.1  nucleolar protein 58 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147254

    9. NM_001420738.1 → NP_001407667.1  nucleolar protein 58 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147254

    10. NM_001420739.1 → NP_001407668.1  nucleolar protein 58 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147254

    11. NM_001420740.1 → NP_001407669.1  nucleolar protein 58 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC147254

    12. NM_001420741.1 → NP_001407670.1  nucleolar protein 58 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC147254

    13. NM_018868.3 → NP_061356.2  nucleolar protein 58 isoform 1

      See identical proteins and their annotated locations for NP_061356.2

      Status: VALIDATED

      Source sequence(s)
      AC147254
      Consensus CDS
      CCDS35587.1
      UniProtKB/Swiss-Prot
      O70396, Q3UYX9, Q3UZA3, Q6DFW4, Q8C8Y7
      Related
      ENSMUSP00000140250.2, ENSMUST00000191142.7
      Conserved Domains (3) summary
      smart00931
      Location:162 → 213
      NOSIC; NOSIC (NUC001) domain
      pfam01798
      Location:168 → 396
      Nop; snoRNA binding domain, fibrillarin
      pfam08156
      Location:2 → 66
      NOP5NT; NOP5NT (NUC127) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      59724165..59751352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFW4.1 GenPept UniProtKB/Swiss-Prot:Q6DFW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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