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    Dclre1a DNA cross-link repair 1A [ Mus musculus (house mouse) ]

    Gene ID: 55947, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dclre1aprovided by MGI
    Official Full Name
    DNA cross-link repair 1Aprovided by MGI
    Primary source
    MGI:MGI:1930042
    See related
    Ensembl:ENSMUSG00000025077 AllianceGenome:MGI:1930042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pso2; Snm1; Smn1a; mKIAA0086; 2810043H12Rik
    Summary
    Predicted to enable 5'-3' exodeoxyribonuclease activity and damaged DNA binding activity. Acts upstream of or within nucleotide-excision repair. Predicted to be located in fibrillar center and nucleoplasm. Orthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.9), liver E14.5 (RPKM 4.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dclre1a in Genome Data Viewer
    Location:
    19 D2; 19 51.89 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56517593..56536716, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56529161..56548284, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family S member 1 Neighboring gene predicted gene, 53193 Neighboring gene NHL repeat containing 2 Neighboring gene STARR-seq mESC enhancer starr_46527 Neighboring gene STARR-seq mESC enhancer starr_46528 Neighboring gene predicted gene, 32441 Neighboring gene predicted gene, 52389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Ahkter S, et al. Mol Cell Biol, 2005 Nov. PMID 16260620, Free PMC Article
    2. The eukaryotic Pso2/Snm1/Artemis proteins and their function as genomic and cellular caretakers. Bonatto D, et al. Braz J Med Biol Res, 2005 Mar. PMID 15761611
    3. Mammalian SNM1 is required for genome stability. Hemphill AW, et al. Mol Genet Metab, 2008 May. PMID 18180189, Free PMC Article
    4. The multifunctional SNM1 gene family: not just nucleases. Yan Y, et al. Future Oncol, 2010 Jun. PMID 20528238, Free PMC Article
    5. SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Akhter S, et al. Biochem Biophys Res Commun, 2008 Dec 5. PMID 18848520, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snm1 is a tumor suppressor in mice that in addition has a role in immunity
      Title: Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.
    2. Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation
      Title: Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0086

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-lactamase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA cross-link repair 1A protein
    Names
    DNA cross-link repair 1A, PSO2 homolog
    SNM1 homolog A
    beta-lactamase MBLAC2
    NP_001347366.2
    NP_001347367.2
    NP_001347368.1
    NP_061301.4
    XP_006527280.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360437.2 → NP_001347366.2  DNA cross-link repair 1A protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166746
      Consensus CDS
      CCDS29917.2
      UniProtKB/Swiss-Prot
      Q571H5, Q6GQR6, Q9JIC3
      UniProtKB/TrEMBL
      S4R1N2, S4R1T3
      Related
      ENSMUSP00000138364.3, ENSMUST00000182059.3
      Conserved Domains (2) summary
      pfam07522
      Location:903 → 1008
      DRMBL; DNA repair metallo-beta-lactamase
      cl23716
      Location:678 → 833
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. NM_001360438.2 → NP_001347367.2  DNA cross-link repair 1A protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166746
      UniProtKB/Swiss-Prot
      Q571H5, Q6GQR6, Q9JIC3
      Conserved Domains (1) summary
      cl23716
      Location:678 → 784
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    3. NM_001360439.1 → NP_001347368.1  DNA cross-link repair 1A protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166746
      Conserved Domains (2) summary
      pfam07522
      Location:385 → 490
      DRMBL; DNA repair metallo-beta-lactamase
      cl23716
      Location:160 → 315
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    4. NM_018831.5 → NP_061301.4  DNA cross-link repair 1A protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166746
      Consensus CDS
      CCDS29917.2
      UniProtKB/Swiss-Prot
      Q571H5, Q6GQR6, Q9JIC3
      UniProtKB/TrEMBL
      S4R1N2, S4R1T3
      Related
      ENSMUSP00000138290.3, ENSMUST00000182276.3
      Conserved Domains (2) summary
      pfam07522
      Location:903 → 1008
      DRMBL; DNA repair metallo-beta-lactamase
      cl23716
      Location:678 → 833
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RNA

    1. NR_153439.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166746
      Related
      ENSMUST00000183143.9

    2. NR_153440.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166746

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      56517593..56536716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527217.3 → XP_006527280.1  DNA cross-link repair 1A protein isoform X1

      See identical proteins and their annotated locations for XP_006527280.1

      UniProtKB/Swiss-Prot
      Q571H5, Q6GQR6, Q9JIC3
      Conserved Domains (2) summary
      pfam07522
      Location:921 → 1026
      DRMBL; DNA repair metallo-beta-lactamase
      cl23716
      Location:696 → 851
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RNA

    1. XR_877682.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIC3.2 GenPept UniProtKB/Swiss-Prot:Q9JIC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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