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    Hgfac hepatocyte growth factor activator [ Mus musculus (house mouse) ]

    Gene ID: 54426, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hgfacprovided by MGI
    Official Full Name
    hepatocyte growth factor activatorprovided by MGI
    Primary source
    MGI:MGI:1859281
    See related
    Ensembl:ENSMUSG00000029102 AllianceGenome:MGI:1859281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HGFA
    Summary
    This gene encodes a serine protease enzyme that proteolytically activates hepatocyte growth factor (HGF) and plays a vital role in the regulation of HGF activity in the regeneration and repair of various tissues. The encoded protein is an inactive zymogen that is proteolytically activated to generate a heterodimeric enzyme consisting of a short chain and a long chain linked by a disulfide bridge. Mice lacking the encoded protein display an impairment in mucosal regeneration after injury. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in colon adult (RPKM 227.5), liver adult (RPKM 215.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hgfac in Genome Data Viewer
    Location:
    5 B2; 5 17.99 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35198853..35205805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35041509..35048461)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Myb/SANT-like DNA-binding domain containing 1 Neighboring gene regulator of G-protein signaling 12 Neighboring gene STARR-seq mESC enhancer starr_12848 Neighboring gene STARR-seq mESC enhancer starr_12849 Neighboring gene microRNA 3097 Neighboring gene docking protein 7 Neighboring gene STARR-seq mESC enhancer starr_12851 Neighboring gene STARR-positive B cell enhancer ABC_E3569 Neighboring gene low density lipoprotein receptor-related protein associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels. Yamagata Y, et al. Am J Physiol Gastrointest Liver Physiol, 2012 Dec 1. PMID 23064758, Free PMC Article
    2. Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice. Itoh H, et al. Gastroenterology, 2004 Nov. PMID 15521012
    3. Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract. Itoh H, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760594
    4. Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells. Ohki T, et al. Biochem Biophys Res Commun, 2012 Aug 31. PMID 22877752
    5. Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. Banna FKE, et al. Sci Rep, 2022 Jun 4. PMID 35661789, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
      Title: HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
    2. HNF1alpha might regulate beta-cell mass or function at least partly by modulating Hgfac expression.
      Title: Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells.
    3. HGFA is required for repair of injured intestinal mucosa but is not essential for normal development during embryogenesis or after birth.
      Title: Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in rough endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte growth factor activator
    Names
    HGF activator
    NP_062320.2
    XP_006504094.1
    XP_006504095.1
    XP_006504096.1
    XP_030110566.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019447.3 → NP_062320.2  hepatocyte growth factor activator preproprotein

      See identical proteins and their annotated locations for NP_062320.2

      Status: REVIEWED

      Source sequence(s)
      AK149522, AK165433, BY195777
      Consensus CDS
      CCDS19223.1
      UniProtKB/Swiss-Prot
      Q9JKV4, Q9R098
      UniProtKB/TrEMBL
      Q545J3, Q8VCS4
      Related
      ENSMUSP00000030985.7, ENSMUST00000030985.10
      Conserved Domains (6) summary
      smart00059
      Location:99 → 145
      FN2; Fibronectin type 2 domain
      smart00020
      Location:405 → 639
      Tryp_SPc; Trypsin-like serine protease
      cd00054
      Location:159 → 194
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:197 → 237
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00190
      Location:406 → 641
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:283 → 364
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35198853..35205805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504031.3 → XP_006504094.1  hepatocyte growth factor activator isoform X1

      UniProtKB/TrEMBL
      Q8VCS4
      Conserved Domains (5) summary
      smart00059
      Location:99 → 145
      FN2; Fibronectin type 2 domain
      cd00054
      Location:159 → 194
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:197 → 237
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00190
      Location:406 → 646
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:283 → 364
      Kringle; Kringle domain

    2. XM_006504032.3 → XP_006504095.1  hepatocyte growth factor activator isoform X2

      UniProtKB/TrEMBL
      Q8VCS4
      Conserved Domains (4) summary
      smart00059
      Location:99 → 145
      FN2; Fibronectin type 2 domain
      cd00054
      Location:159 → 194
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:362 → 602
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:239 → 320
      Kringle; Kringle domain

    3. XM_030254706.1 → XP_030110566.1  hepatocyte growth factor activator isoform X3

      UniProtKB/TrEMBL
      Q8VCS4
      Conserved Domains (4) summary
      smart00059
      Location:99 → 145
      FN2; Fibronectin type 2 domain
      cd00054
      Location:159 → 194
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:362 → 597
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00051
      Location:239 → 320
      Kringle; Kringle domain

    4. XM_006504033.1 → XP_006504096.1  hepatocyte growth factor activator isoform X4

      Conserved Domains (4) summary
      smart00059
      Location:99 → 145
      FN2; Fibronectin type 2 domain
      cd00054
      Location:159 → 194
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:197 → 237
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00051
      Location:283 → 364
      Kringle; Kringle domain

    RNA

    1. XR_376817.1 RNA Sequence

    2. XR_003955676.1 RNA Sequence

    3. XR_376819.4 RNA Sequence

    4. XR_376818.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R098.1 GenPept UniProtKB/Swiss-Prot:Q9R098

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