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    Cpq carboxypeptidase Q [ Mus musculus (house mouse) ]

    Gene ID: 54381, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cpqprovided by MGI
    Official Full Name
    carboxypeptidase Qprovided by MGI
    Primary source
    MGI:MGI:1889205
    See related
    Ensembl:ENSMUSG00000039007 AllianceGenome:MGI:1889205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hls2; Pgcp; Lal-1; 1190003P12Rik; 2610034C17Rik
    Summary
    Predicted to enable metallodipeptidase activity and protein homodimerization activity. Predicted to be involved in peptide catabolic process; proteolysis; and thyroid hormone generation. Located in lysosome. Is expressed in genitourinary system. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 26.1), subcutaneous fat pad adult (RPKM 15.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B3.1; 15 13.74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (33083275..33594698)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (33083129..33594552)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53871 Neighboring gene syndecan 2 Neighboring gene STARR-seq mESC enhancer starr_38300 Neighboring gene STARR-seq mESC enhancer starr_38301 Neighboring gene predicted gene, 32764 Neighboring gene STARR-seq mESC enhancer starr_38302 Neighboring gene STARR-seq mESC enhancer starr_38303 Neighboring gene ribosomal protein L7-like 1 pseudogene Neighboring gene RIKEN cDNA 4930592A05 gene Neighboring gene STARR-seq mESC enhancer starr_38305 Neighboring gene predicted gene, 53872 Neighboring gene testis-specific protein, Y-encoded-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation. Della Fazia MA, et al. J Cell Sci, 2005 Jul 15. PMID 16014383
    2. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article
    3. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallodipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase Q
    Names
    hematopoietic lineage switch 2
    plasma glutamate carboxypeptidase
    NP_061225.2
    NP_788262.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018755.2 → NP_061225.2  carboxypeptidase Q precursor

      See identical proteins and their annotated locations for NP_061225.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK152145, BB472698, CK624628
      Consensus CDS
      CCDS27414.1
      UniProtKB/Swiss-Prot
      O70216, Q3U8N9, Q9WVJ3
      Related
      ENSMUSP00000154400.2, ENSMUST00000228916.2
      Conserved Domains (2) summary
      cd03883
      Location:45 → 447
      M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
      cd04815
      Location:128 → 254
      PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

    2. NM_176073.4 → NP_788262.1  carboxypeptidase Q precursor

      See identical proteins and their annotated locations for NP_788262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK135096, BB472698, CK624628
      Consensus CDS
      CCDS27414.1
      UniProtKB/Swiss-Prot
      O70216, Q3U8N9, Q9WVJ3
      Related
      ENSMUSP00000039046.10, ENSMUST00000042167.10
      Conserved Domains (2) summary
      cd03883
      Location:45 → 447
      M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
      cd04815
      Location:128 → 254
      PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      33083275..33594698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVJ3.1 GenPept UniProtKB/Swiss-Prot:Q9WVJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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