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    Elp5 elongator acetyltransferase complex subunit 5 [ Mus musculus (house mouse) ]

    Gene ID: 54351, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Elp5provided by MGI
    Official Full Name
    elongator acetyltransferase complex subunit 5provided by MGI
    Primary source
    MGI:MGI:1859017
    See related
    Ensembl:ENSMUSG00000018565 AllianceGenome:MGI:1859017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Derp6; Rai12
    Summary
    Predicted to contribute to tRNA binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol and nucleus. Is expressed in genitourinary system and telencephalon. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 72.9), CNS E18 (RPKM 36.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 42.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69859050..69872352, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69968224..69981447, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene claudin 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69793405-69793588 Neighboring gene STARR-positive B cell enhancer ABC_E3967 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69804503-69804686 Neighboring gene STARR-positive B cell enhancer ABC_E2997 Neighboring gene gamma-aminobutyric acid receptor associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69808904-69809245 Neighboring gene PHD finger protein 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important growth regulator of melanoma. Spanjaard RA, et al. Cancer Res, 1997 Nov 15. PMID 9371513
    2. Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Creppe C, et al. Cell, 2009 Feb 6. PMID 19185337
    3. Cryo-EM structure of the fully assembled Elongator complex. Jaciuk M, et al. Nucleic Acids Res, 2023 Mar 21. PMID 36617428, Free PMC Article
    4. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Close P, et al. J Biol Chem, 2012 Sep 21. PMID 22854966, Free PMC Article
    5. Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. Freeman S, et al. EMBO Rep, 2019 Sep. PMID 31321879, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongator complex protein 5
    Names
    dermal papilla-derived protein 6 homolog
    retinoic acid induced 12
    retinoic acid-induced protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253700.1 → NP_001240629.1  elongator complex protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001240629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA646690, AL596185, BE862527, CD741073
      Conserved Domains (1) summary
      pfam10483
      Location:105 → 150
      Elong_Iki1; Elongator subunit Iki1

    2. NM_018740.2 → NP_061210.2  elongator complex protein 5 isoform 1

      See identical proteins and their annotated locations for NP_061210.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK152582, CD776986
      Consensus CDS
      CCDS24926.1
      UniProtKB/Swiss-Prot
      O08973, Q99L85, Q9CUX2
      Related
      ENSMUSP00000104235.2, ENSMUST00000108594.8
      Conserved Domains (1) summary
      pfam10483
      Location:11 → 282
      Elong_Iki1; Elongator subunit Iki1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69859050..69872352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533752.5 → XP_006533815.1  elongator complex protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006533815.1

      UniProtKB/Swiss-Prot
      O08973, Q99L85, Q9CUX2
      Conserved Domains (1) summary
      pfam10483
      Location:11 → 282
      Elong_Iki1; Elongator subunit Iki1

    2. XM_030246159.1 → XP_030102019.1  elongator complex protein 5 isoform X2

      Conserved Domains (1) summary
      pfam10483
      Location:105 → 150
      Elong_Iki1; Elongator subunit Iki1

    3. XM_036156855.1 → XP_036012748.1  elongator complex protein 5 isoform X2

      Conserved Domains (1) summary
      pfam10483
      Location:105 → 150
      Elong_Iki1; Elongator subunit Iki1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_027884.1: Suppressed sequence

      Description
      NR_027884.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which retains intronic sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L85.1 GenPept UniProtKB/Swiss-Prot:Q99L85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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